PTPRC and CD2

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		PTPRC	CD2
Description		protein tyrosine phosphatase receptor type C	CD2 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Secretory Granule Membrane Bleb Membrane Raft Extracellular Exosome Membrane Microdomain	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Protein-containing Complex Membrane Raft Anchored Component Of Plasma Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Heparin Binding Protein Kinase Binding Ankyrin Binding Spectrin Binding Heparan Sulfate Proteoglycan Binding	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding Protein Self-association
	Biological Process	Activation Of MAPK Activity Natural Killer Cell Differentiation Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Immunoglobulin Production Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Response To Gamma Radiation Regulation Of Gene Expression Viral Process Dephosphorylation B Cell Differentiation T Cell Differentiation Positive Regulation Of B Cell Proliferation Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Autophosphorylation Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Peptidyl-tyrosine Dephosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Neutrophil Degranulation Positive Regulation Of MAPK Cascade Cell Cycle Phase Transition Plasma Membrane Raft Distribution Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Protein Kinase Activity Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Stem Cell Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Phagocytosis T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Tyrosine Phosphatase Activity Negative Regulation Of Microglial Cell Activation DN2 Thymocyte Differentiation Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Cell-cell Adhesion
Pathways		Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation	Cell surface interactions at the vascular wall
Drugs			Alefacept Siplizumab
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Apolipoprotein B levels ( 32203549) Asthma ( 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 26192919 28067908) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 20139978 28017375) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966) Ulcerative colitis ( 24837172) Vitiligo ( 27723757) White blood cell count ( 32888494)	Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		45 interacting genes: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MAPK1 MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 SRC TYK2 UHRF2 ZAP70	21 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1 UBC
Entrez ID		5788	914
HPRD ID		01050	01750
Ensembl ID		ENSG00000081237	ENSG00000116824
Uniprot IDs		M9MML4 P08575	P06729 Q53F96
PDB IDs		1YGR 1YGU 5FMV 5FN6 5FN7	1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?
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