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CD4 and CD38
Data Source:
HPRD
(in vitro)
CD4
CD38
Description
CD4 molecule
CD38 molecule
Image
GO Annotations
Cellular Component
Early Endosome
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Clathrin-coated Vesicle Membrane
T Cell Receptor Complex
Membrane Raft
Nucleus
Plasma Membrane
Cell Surface
Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Secretory Granule Membrane
Extracellular Exosome
Molecular Function
Virus Receptor Activity
Transmembrane Signaling Receptor Activity
Extracellular Matrix Structural Constituent
Protein Binding
Zinc Ion Binding
Coreceptor Activity
Immunoglobulin Binding
Enzyme Binding
Protein Kinase Binding
MHC Class II Protein Complex Binding
Signaling Receptor Activity
Interleukin-16 Binding
Interleukin-16 Receptor Activity
MHC Class II Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Tyrosine Kinase Binding
NAD+ Nucleosidase Activity
Transferase Activity
Phosphorus-oxygen Lyase Activity
Identical Protein Binding
NAD(P)+ Nucleosidase Activity
NAD+ Nucleotidase, Cyclic ADP-ribose Generating
Biological Process
Positive Regulation Of Protein Phosphorylation
Adaptive Immune Response
Induction By Virus Of Host Cell-cell Fusion
Immune Response
Cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Calcium Ion Transport Into Cytosol
Fusion Of Virus Membrane With Host Plasma Membrane
Cytokine-mediated Signaling Pathway
T Cell Differentiation
Macrophage Differentiation
Response To Estradiol
Maintenance Of Protein Location In Cell
Positive Regulation Of Interleukin-2 Production
Response To Vitamin D
Positive Regulation Of Kinase Activity
Helper T Cell Enhancement Of Adaptive Immune Response
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
T Cell Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
T Cell Selection
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Viral Entry Into Host Cell
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-negative Bacterium
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Regulation Of T Cell Activation
Regulation Of Calcium Ion Transport
Membrane Organization
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Response To Hypoxia
Signal Transduction
Positive Regulation Of Cytosolic Calcium Ion Concentration
Female Pregnancy
Negative Regulation Of Neuron Projection Development
Artery Smooth Muscle Contraction
NAD Metabolic Process
Positive Regulation Of Cell Growth
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Insulin Secretion
Response To Estradiol
Response To Retinoic Acid
Response To Progesterone
Response To Hydroperoxide
Response To Drug
Negative Regulation Of Apoptotic Process
Negative Regulation Of Bone Resorption
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Vasoconstriction
B Cell Receptor Signaling Pathway
Long-term Synaptic Depression
Response To Interleukin-1
Apoptotic Signaling Pathway
Pathways
Alpha-defensins
Nef Mediated CD4 Down-regulation
Binding and entry of HIV virion
Vpu mediated degradation of CD4
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
Other interleukin signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Nicotinate metabolism
Drugs
Antithymocyte immunoglobulin (rabbit)
Clenoliximab
Ibalizumab
Daratumumab
Isatuximab
Mezagitamab
Diseases
GWAS
Bone mineral density (hip) (
30172743
)
Response to Vitamin E supplementation (
22437554
)
Blood protein levels (
28240269
)
Neurological blood protein biomarker levels (
31320639
)
Parkinson's disease (
27182965
28892059
)
Interacting Genes
38 interacting genes:
ABCB1
ADRB2
CCR5
CD2
CD28
CD38
CD44
CD5
CD53
CD82
CTSD
CXCL12
CXCR4
DPP4
FCGR3A
HLA-DPA1
HLA-DQA2
HLA-DQB1
IL16
IL2RA
INPPL1
KCNAB2
LAT
LCK
LGALS1
MAPK14
MARCHF4
PI4KA
PIK3R1
PIP
PTPRC
SELL
SIVA1
SPG21
TFRC
TNFRSF10A
UBL7
UNC119
6 interacting genes:
CBL
CD4
CD9
FCGR3A
LCK
PECAM1
Entrez ID
920
952
HPRD ID
01740
00116
Ensembl ID
ENSG00000010610
ENSG00000004468
Uniprot IDs
A0A4Y5UGE4
B0AZV7
B4DT49
P01730
B4E006
P28907
PDB IDs
1CDH
1CDI
1CDJ
1CDU
1CDY
1G9M
1G9N
1GC1
1JL4
1OPN
1OPT
1OPW
1Q68
1RZJ
1RZK
1WBR
1WIO
1WIP
1WIQ
2B4C
2JKR
2JKT
2KLU
2NXY
2NXZ
2NY0
2NY1
2NY2
2NY3
2NY4
2NY5
2NY6
2QAD
3B71
3CD4
3J70
3JCB
3JCC
3JWD
3JWO
3LQA
3O2D
3S4S
3S5L
3T0E
4H8W
4JM2
4P9H
4Q6I
4R2G
4R4H
4RQS
5A7X
5A8H
5CAY
5THR
5U1F
5VN3
6CM3
6EDU
6L1Y
6MEO
6MET
6OPN
6OPO
6OPP
6OPQ
6QH6
6QH7
6U0L
6U0N
6URI
6X5B
6X5C
1YH3
1ZVM
2EF1
2HCT
2I65
2I66
2I67
2O3Q
2O3R
2O3S
2O3T
2O3U
2PGJ
2PGL
3DZF
3DZG
3DZH
3DZI
3DZJ
3DZK
3F6Y
3I9M
3I9N
3OFS
3RAJ
3ROK
3ROM
3ROP
3ROQ
3U4H
3U4I
4CMH
4F45
4F46
4OGW
4TMF
4XJS
4XJT
5F1K
5F1O
5F21
6EDR
6VUA
Enriched GO Terms of Interacting Partners
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