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CD4 and UBL7
Data Source:
BioGRID
(two hybrid)
CD4
UBL7
Description
CD4 molecule
ubiquitin like 7
Image
GO Annotations
Cellular Component
Early Endosome
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Clathrin-coated Vesicle Membrane
T Cell Receptor Complex
Membrane Raft
Cytosol
Molecular Function
Virus Receptor Activity
Transmembrane Signaling Receptor Activity
Extracellular Matrix Structural Constituent
Protein Binding
Zinc Ion Binding
Coreceptor Activity
Immunoglobulin Binding
Enzyme Binding
Protein Kinase Binding
MHC Class II Protein Complex Binding
Signaling Receptor Activity
Interleukin-16 Binding
Interleukin-16 Receptor Activity
MHC Class II Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Tyrosine Kinase Binding
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Adaptive Immune Response
Induction By Virus Of Host Cell-cell Fusion
Immune Response
Cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Calcium Ion Transport Into Cytosol
Fusion Of Virus Membrane With Host Plasma Membrane
Cytokine-mediated Signaling Pathway
T Cell Differentiation
Macrophage Differentiation
Response To Estradiol
Maintenance Of Protein Location In Cell
Positive Regulation Of Interleukin-2 Production
Response To Vitamin D
Positive Regulation Of Kinase Activity
Helper T Cell Enhancement Of Adaptive Immune Response
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
T Cell Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
T Cell Selection
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Viral Entry Into Host Cell
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-negative Bacterium
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Regulation Of T Cell Activation
Regulation Of Calcium Ion Transport
Membrane Organization
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Ubiquitin-dependent Protein Catabolic Process
Pathways
Alpha-defensins
Nef Mediated CD4 Down-regulation
Binding and entry of HIV virion
Vpu mediated degradation of CD4
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
Other interleukin signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
Antithymocyte immunoglobulin (rabbit)
Clenoliximab
Ibalizumab
Diseases
GWAS
Bone mineral density (hip) (
30172743
)
Response to Vitamin E supplementation (
22437554
)
Craniofacial microsomia (
26853712
)
Eosinophil percentage of white cells (
32888494
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Metabolite levels (
23823483
)
Interacting Genes
38 interacting genes:
ABCB1
ADRB2
CCR5
CD2
CD28
CD38
CD44
CD5
CD53
CD82
CTSD
CXCL12
CXCR4
DPP4
FCGR3A
HLA-DPA1
HLA-DQA2
HLA-DQB1
IL16
IL2RA
INPPL1
KCNAB2
LAT
LCK
LGALS1
MAPK14
MARCHF4
PI4KA
PIK3R1
PIP
PTPRC
SELL
SIVA1
SPG21
TFRC
TNFRSF10A
UBL7
UNC119
16 interacting genes:
AP1G1
BAG6
CAPN7
CD4
CDKN2A
ERCC1
ESRRG
IDH1
MFHAS1
MYBPH
NEDD8
RAD23A
RXRB
SH3GLB1
UBC
VBP1
Entrez ID
920
84993
HPRD ID
01740
16556
Ensembl ID
ENSG00000010610
ENSG00000138629
Uniprot IDs
A0A4Y5UGE4
B0AZV7
B4DT49
P01730
D3DW56
Q96S82
PDB IDs
1CDH
1CDI
1CDJ
1CDU
1CDY
1G9M
1G9N
1GC1
1JL4
1OPN
1OPT
1OPW
1Q68
1RZJ
1RZK
1WBR
1WIO
1WIP
1WIQ
2B4C
2JKR
2JKT
2KLU
2NXY
2NXZ
2NY0
2NY1
2NY2
2NY3
2NY4
2NY5
2NY6
2QAD
3B71
3CD4
3J70
3JCB
3JCC
3JWD
3JWO
3LQA
3O2D
3S4S
3S5L
3T0E
4H8W
4JM2
4P9H
4Q6I
4R2G
4R4H
4RQS
5A7X
5A8H
5CAY
5THR
5U1F
5VN3
6CM3
6EDU
6L1Y
6MEO
6MET
6OPN
6OPO
6OPP
6OPQ
6QH6
6QH7
6U0L
6U0N
6URI
6X5B
6X5C
2CWB
2DEN
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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