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CD4 and ADRB2
Data Source:
BioGRID
(protein complementation assay, affinity chromatography technology)
CD4
ADRB2
Description
CD4 molecule
adrenoceptor beta 2
Image
GO Annotations
Cellular Component
Early Endosome
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Clathrin-coated Vesicle Membrane
T Cell Receptor Complex
Membrane Raft
Nucleus
Lysosome
Endosome
Early Endosome
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Endosome Membrane
Membrane
Apical Plasma Membrane
Clathrin-coated Vesicle Membrane
Receptor Complex
Molecular Function
Virus Receptor Activity
Transmembrane Signaling Receptor Activity
Extracellular Matrix Structural Constituent
Protein Binding
Zinc Ion Binding
Coreceptor Activity
Immunoglobulin Binding
Enzyme Binding
Protein Kinase Binding
MHC Class II Protein Complex Binding
Signaling Receptor Activity
Interleukin-16 Binding
Interleukin-16 Receptor Activity
MHC Class II Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Tyrosine Kinase Binding
Amyloid-beta Binding
G Protein-coupled Receptor Activity
Beta2-adrenergic Receptor Activity
Protein Binding
Adenylate Cyclase Binding
Potassium Channel Regulator Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Norepinephrine Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Adaptive Immune Response
Induction By Virus Of Host Cell-cell Fusion
Immune Response
Cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Calcium Ion Transport Into Cytosol
Fusion Of Virus Membrane With Host Plasma Membrane
Cytokine-mediated Signaling Pathway
T Cell Differentiation
Macrophage Differentiation
Response To Estradiol
Maintenance Of Protein Location In Cell
Positive Regulation Of Interleukin-2 Production
Response To Vitamin D
Positive Regulation Of Kinase Activity
Helper T Cell Enhancement Of Adaptive Immune Response
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
T Cell Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
T Cell Selection
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Viral Entry Into Host Cell
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-negative Bacterium
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Regulation Of T Cell Activation
Regulation Of Calcium Ion Transport
Membrane Organization
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Diet Induced Thermogenesis
Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure
Regulation Of Sodium Ion Transport
Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin
Receptor-mediated Endocytosis
Cell Surface Receptor Signaling Pathway
Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Endosome To Lysosome Transport
Response To Cold
Positive Regulation Of Protein Kinase A Signaling
Protein Deubiquitination
Positive Regulation Of Bone Mineralization
Heat Generation
Negative Regulation Of Multicellular Organism Growth
Positive Regulation Of MAPK Cascade
Bone Resorption
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Smooth Muscle Contraction
Brown Fat Cell Differentiation
Membrane Organization
Positive Regulation Of Mini Excitatory Postsynaptic Potential
Adrenergic Receptor Signaling Pathway
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Autophagosome Maturation
Positive Regulation Of Lipophagy
Cellular Response To Amyloid-beta
Response To Psychosocial Stress
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Positive Regulation Of AMPA Receptor Activity
Pathways
Alpha-defensins
Nef Mediated CD4 Down-regulation
Binding and entry of HIV virion
Vpu mediated degradation of CD4
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
Other interleukin signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Adrenoceptors
G alpha (s) signalling events
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Antithymocyte immunoglobulin (rabbit)
Clenoliximab
Ibalizumab
Spermine
Amphetamine
Betaxolol
Bethanidine
Isoetharine
Cabergoline
Metoprolol
Olanzapine
Atenolol
Norepinephrine
Timolol
Phenylpropanolamine
Dipivefrin
Sotalol
Carteolol
Nortriptyline
Propranolol
Labetalol
Bisoprolol
Epinephrine
Paroxetine
Trimipramine
Cryptenamine
Orciprenaline
Dobutamine
Pseudoephedrine
Alprenolol
Ritodrine
Terbutaline
Bitolterol
Phenoxybenzamine
Salmeterol
Pindolol
Formoterol
Salbutamol
Ergoloid mesylate
Isoprenaline
Arbutamine
Amiodarone
Carvedilol
Desipramine
Propafenone
Acebutolol
Nadolol
Levobunolol
Metipranolol
Aripiprazole
Arformoterol
Fenoterol
Pirbuterol
Bevantolol
Penbutolol
Ephedra sinica root
Ephedrine
Mephentermine
Procaterol
Clenbuterol
Bambuterol
Oxprenolol
Putrescine
Spermidine
Celiprolol
Nebivolol
Indacaterol
Bedoradrine
NCX 950
Asenapine
Droxidopa
Bufuralol
Protokylol
(S)-carazolol
Bopindolol
Bupranolol
Befunolol
Olodaterol
Vilanterol
Arotinolol
Doxofylline
Racepinephrine
Dihydroergocornine
DL-Methylephedrine
Etafedrine
Tulobuterol
Levosalbutamol
Dihydroergocristine
Diseases
Asthma
GWAS
Bone mineral density (hip) (
30172743
)
Response to Vitamin E supplementation (
22437554
)
Chronic obstructive pulmonary disease (
30804561
)
Eosinophil percentage of white cells (
32888494
)
FEV1 (
30804560
)
Lung function (FEV1/FVC) (
30804560
)
Lymphocyte percentage of white cells (
27863252
)
Peak expiratory flow (
30804560
)
Systolic blood pressure (
29615537
)
Interacting Genes
38 interacting genes:
ABCB1
ADRB2
CCR5
CD2
CD28
CD38
CD44
CD5
CD53
CD82
CTSD
CXCL12
CXCR4
DPP4
FCGR3A
HLA-DPA1
HLA-DQA2
HLA-DQB1
IL16
IL2RA
INPPL1
KCNAB2
LAT
LCK
LGALS1
MAPK14
MARCHF4
PI4KA
PIK3R1
PIP
PTPRC
SELL
SIVA1
SPG21
TFRC
TNFRSF10A
UBL7
UNC119
160 interacting genes:
ABCA7
ADGRG1
ADRB3
AKAP12
AKAP5
ALDOA
ARF4
ARHGAP5
ARHGDIA
ARR3
ARRB1
ARRB2
ARRDC3
ARV1
ATP6V0B
ATP6V0D1
BACE1
BAZ2A
BSG
CAV3
CCKBR
CCND2
CD4
CD68
CD81
CD9
CEACAM1
CENPB
CLASP2
CLPTM1L
CNN1
CRYM
CSK
DCAF10
DCLRE1A
DNAJC14
DRD4
EGLN3
EIF2B1
FBXO17
GBP5
GJC2
GMPR2
GNA11
GNA14
GNA15
GNAI1
GNAI2
GNAS
GNAT2
GNB1
GNG2
GNL3L
GOLGB1
GPR37
GPRASP1
GPRC5B
GRB2
GRIA3
GRK1
GRK2
GRK3
GRK4
GRK5
GRK6
GTF2B
HDAC6
HNRNPK
HS2ST1
HTR4
IL1B
IL6R
INSR
KCNE1
KCNJ5
KCNJ6
KCNJ9
KCTD13
KLC1
LRATD2
MAPK8IP2
MBOAT2
MBP
MCAM
MDM2
MFSD12
MFSD2A
MGLL
MITF
MOG
MSR1
NAT14
NCOR2
NEDD4
NIPAL2
NOS1
NPTX1
OBP2A
OPRD1
PLA2G2D
PRDX1
PRKCD
PRNP
PTGDS
PTGER1
PTGES2
RAB14
RAB27A
RAB3A
RACK1
RAN
RAP2C
REL
RGR
RGS10
RGS11
RGS17
RGS2
RGS20
RGS5
RGS8
RGS9
RHOD
RIOX1
RNF41
RTN1
SACS
SENP3
SI
SLC37A1
SLC39A4
SLC52A2
SLC9A3R1
SLC9A3R2
SNCA
SNCG
SPTBN2
SRC
STAT3
STAT4
TCTA
TMCC2
TMEM144
TMEM187
TMEM259
TPTE
TSG101
TSHR
TSPAN7
UCHL1
UST
VAPA
VDAC1
VDAC2
VEGFB
WNK1
YIPF5
YWHAQ
ZNF25
ZNF254
Entrez ID
920
154
HPRD ID
01740
00187
Ensembl ID
ENSG00000010610
ENSG00000169252
Uniprot IDs
A0A4Y5UGE4
B0AZV7
B4DT49
P01730
P07550
X5DQM5
PDB IDs
1CDH
1CDI
1CDJ
1CDU
1CDY
1G9M
1G9N
1GC1
1JL4
1OPN
1OPT
1OPW
1Q68
1RZJ
1RZK
1WBR
1WIO
1WIP
1WIQ
2B4C
2JKR
2JKT
2KLU
2NXY
2NXZ
2NY0
2NY1
2NY2
2NY3
2NY4
2NY5
2NY6
2QAD
3B71
3CD4
3J70
3JCB
3JCC
3JWD
3JWO
3LQA
3O2D
3S4S
3S5L
3T0E
4H8W
4JM2
4P9H
4Q6I
4R2G
4R4H
4RQS
5A7X
5A8H
5CAY
5THR
5U1F
5VN3
6CM3
6EDU
6L1Y
6MEO
6MET
6OPN
6OPO
6OPP
6OPQ
6QH6
6QH7
6U0L
6U0N
6URI
6X5B
6X5C
1GQ4
2R4R
2R4S
2RH1
3D4S
3KJ6
3NY8
3NY9
3NYA
3P0G
3PDS
3SN6
4GBR
4LDE
4LDL
4LDO
4QKX
5D5A
5D5B
5D6L
5JQH
5X7D
6E67
6KR8
6MXT
6N48
6NI3
6OBA
6PRZ
6PS0
6PS1
6PS2
6PS3
6PS4
6PS5
6PS6
7BZ2
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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