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CD4 and CTSD
Data Source:
HPRD
(in vitro)
CD4
CTSD
Description
CD4 molecule
cathepsin D
Image
GO Annotations
Cellular Component
Early Endosome
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Clathrin-coated Vesicle Membrane
T Cell Receptor Complex
Membrane Raft
Extracellular Region
Extracellular Space
Lysosome
Lysosomal Membrane
Endosome Membrane
Specific Granule Lumen
Melanosome
Lysosomal Lumen
Membrane Raft
Collagen-containing Extracellular Matrix
Extracellular Exosome
Tertiary Granule Lumen
Ficolin-1-rich Granule Lumen
Molecular Function
Virus Receptor Activity
Transmembrane Signaling Receptor Activity
Extracellular Matrix Structural Constituent
Protein Binding
Zinc Ion Binding
Coreceptor Activity
Immunoglobulin Binding
Enzyme Binding
Protein Kinase Binding
MHC Class II Protein Complex Binding
Signaling Receptor Activity
Interleukin-16 Binding
Interleukin-16 Receptor Activity
MHC Class II Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Tyrosine Kinase Binding
Aspartic-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Aspartic-type Peptidase Activity
Biological Process
Positive Regulation Of Protein Phosphorylation
Adaptive Immune Response
Induction By Virus Of Host Cell-cell Fusion
Immune Response
Cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Calcium Ion Transport Into Cytosol
Fusion Of Virus Membrane With Host Plasma Membrane
Cytokine-mediated Signaling Pathway
T Cell Differentiation
Macrophage Differentiation
Response To Estradiol
Maintenance Of Protein Location In Cell
Positive Regulation Of Interleukin-2 Production
Response To Vitamin D
Positive Regulation Of Kinase Activity
Helper T Cell Enhancement Of Adaptive Immune Response
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
T Cell Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
T Cell Selection
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Viral Entry Into Host Cell
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-negative Bacterium
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Regulation Of T Cell Activation
Regulation Of Calcium Ion Transport
Membrane Organization
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Proteolysis
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Collagen Catabolic Process
Lipoprotein Catabolic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Neutrophil Degranulation
Regulation Of Establishment Of Protein Localization
Pathways
Alpha-defensins
Nef Mediated CD4 Down-regulation
Binding and entry of HIV virion
Vpu mediated degradation of CD4
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
Other interleukin signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Collagen degradation
Metabolism of Angiotensinogen to Angiotensins
MHC class II antigen presentation
Neutrophil degranulation
Estrogen-dependent gene expression
Drugs
Antithymocyte immunoglobulin (rabbit)
Clenoliximab
Ibalizumab
Insulin pork
S-Methylcysteine
1h-Benoximidazole-2-Carboxylic Acid
2-Morpholinoethylamine
5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID
CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE
Diseases
Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS
Bone mineral density (hip) (
30172743
)
Response to Vitamin E supplementation (
22437554
)
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Logical memory (delayed recall) in mild cognitive impairment (
29274321
)
Interacting Genes
38 interacting genes:
ABCB1
ADRB2
CCR5
CD2
CD28
CD38
CD44
CD5
CD53
CD82
CTSD
CXCL12
CXCR4
DPP4
FCGR3A
HLA-DPA1
HLA-DQA2
HLA-DQB1
IL16
IL2RA
INPPL1
KCNAB2
LAT
LCK
LGALS1
MAPK14
MARCHF4
PI4KA
PIK3R1
PIP
PTPRC
SELL
SIVA1
SPG21
TFRC
TNFRSF10A
UBL7
UNC119
24 interacting genes:
APP
BGLAP
CCL21
CD4
CST3
CSTB
CTSB
FN1
HSPB2
IGF2R
IGFBP3
IGFBP4
INS
MAPK1
MAPT
NEAT1
NLGN3
PSAP
SERPINA4
SHBG
SLC2A4
SNCA
SPRED2
TG
Entrez ID
920
1509
HPRD ID
01740
00291
Ensembl ID
ENSG00000010610
ENSG00000117984
Uniprot IDs
A0A4Y5UGE4
B0AZV7
B4DT49
P01730
P07339
V9HWI3
PDB IDs
1CDH
1CDI
1CDJ
1CDU
1CDY
1G9M
1G9N
1GC1
1JL4
1OPN
1OPT
1OPW
1Q68
1RZJ
1RZK
1WBR
1WIO
1WIP
1WIQ
2B4C
2JKR
2JKT
2KLU
2NXY
2NXZ
2NY0
2NY1
2NY2
2NY3
2NY4
2NY5
2NY6
2QAD
3B71
3CD4
3J70
3JCB
3JCC
3JWD
3JWO
3LQA
3O2D
3S4S
3S5L
3T0E
4H8W
4JM2
4P9H
4Q6I
4R2G
4R4H
4RQS
5A7X
5A8H
5CAY
5THR
5U1F
5VN3
6CM3
6EDU
6L1Y
6MEO
6MET
6OPN
6OPO
6OPP
6OPQ
6QH6
6QH7
6U0L
6U0N
6URI
6X5B
6X5C
1LYA
1LYB
1LYW
4OBZ
4OC6
4OD9
Enriched GO Terms of Interacting Partners
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