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ADRB2 and ARRB1
Data Source:
HPRD
(in vivo)
ADRB2
ARRB1
Description
adrenoceptor beta 2
arrestin beta 1
Image
GO Annotations
Cellular Component
Nucleus
Lysosome
Endosome
Early Endosome
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Endosome Membrane
Membrane
Apical Plasma Membrane
Clathrin-coated Vesicle Membrane
Receptor Complex
Golgi Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Lysosomal Membrane
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Postsynaptic Density
Basolateral Plasma Membrane
Nuclear Body
Cytoplasmic Vesicle Membrane
Pseudopodium
Cytoplasmic Vesicle
Dendritic Spine
Postsynaptic Membrane
Molecular Function
Amyloid-beta Binding
G Protein-coupled Receptor Activity
Beta2-adrenergic Receptor Activity
Protein Binding
Adenylate Cyclase Binding
Potassium Channel Regulator Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Norepinephrine Binding
G Protein-coupled Receptor Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Enzyme Inhibitor Activity
GTPase Activator Activity
Insulin-like Growth Factor Receptor Binding
Protein Binding
Transcription Factor Binding
Estrogen Receptor Binding
Ubiquitin Protein Ligase Binding
Alpha-1A Adrenergic Receptor Binding
Alpha-1B Adrenergic Receptor Binding
Angiotensin Receptor Binding
Follicle-stimulating Hormone Receptor Binding
V2 Vasopressin Receptor Binding
AP-2 Adaptor Complex Binding
Clathrin Adaptor Activity
Ion Channel Binding
Protein Phosphorylated Amino Acid Binding
Arrestin Family Protein Binding
Biological Process
Diet Induced Thermogenesis
Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure
Regulation Of Sodium Ion Transport
Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin
Receptor-mediated Endocytosis
Cell Surface Receptor Signaling Pathway
Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Endosome To Lysosome Transport
Response To Cold
Positive Regulation Of Protein Kinase A Signaling
Protein Deubiquitination
Positive Regulation Of Bone Mineralization
Heat Generation
Negative Regulation Of Multicellular Organism Growth
Positive Regulation Of MAPK Cascade
Bone Resorption
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Smooth Muscle Contraction
Brown Fat Cell Differentiation
Membrane Organization
Positive Regulation Of Mini Excitatory Postsynaptic Potential
Adrenergic Receptor Signaling Pathway
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Autophagosome Maturation
Positive Regulation Of Lipophagy
Cellular Response To Amyloid-beta
Response To Psychosocial Stress
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Positive Regulation Of AMPA Receptor Activity
Activation Of MAPK Activity
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
G Protein-coupled Receptor Internalization
Positive Regulation Of Receptor Internalization
Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Protein Transport
Protein Ubiquitination
Histone Acetylation
Platelet Activation
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Interleukin-8 Production
Negative Regulation Of GTPase Activity
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Rho Protein Signal Transduction
Positive Regulation Of Histone Acetylation
Response To Drug
Follicle-stimulating Hormone Signaling Pathway
Stress Fiber Assembly
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Membrane Organization
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Histone H4 Acetylation
Pathways
Adrenoceptors
G alpha (s) signalling events
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
ADORA2B mediated anti-inflammatory cytokines production
Activated NOTCH1 Transmits Signal to the Nucleus
G alpha (s) signalling events
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Thrombin signalling through proteinase activated receptors (PARs)
Activation of SMO
Activation of SMO
MAP2K and MAPK activation
Ub-specific processing proteases
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Spermine
Amphetamine
Betaxolol
Bethanidine
Isoetharine
Cabergoline
Metoprolol
Olanzapine
Atenolol
Norepinephrine
Timolol
Phenylpropanolamine
Dipivefrin
Sotalol
Carteolol
Nortriptyline
Propranolol
Labetalol
Bisoprolol
Epinephrine
Paroxetine
Trimipramine
Cryptenamine
Orciprenaline
Dobutamine
Pseudoephedrine
Alprenolol
Ritodrine
Terbutaline
Bitolterol
Phenoxybenzamine
Salmeterol
Pindolol
Formoterol
Salbutamol
Ergoloid mesylate
Isoprenaline
Arbutamine
Amiodarone
Carvedilol
Desipramine
Propafenone
Acebutolol
Nadolol
Levobunolol
Metipranolol
Aripiprazole
Arformoterol
Fenoterol
Pirbuterol
Bevantolol
Penbutolol
Ephedra sinica root
Ephedrine
Mephentermine
Procaterol
Clenbuterol
Bambuterol
Oxprenolol
Putrescine
Spermidine
Celiprolol
Nebivolol
Indacaterol
Bedoradrine
NCX 950
Asenapine
Droxidopa
Bufuralol
Protokylol
(S)-carazolol
Bopindolol
Bupranolol
Befunolol
Olodaterol
Vilanterol
Arotinolol
Doxofylline
Racepinephrine
Dihydroergocornine
DL-Methylephedrine
Etafedrine
Tulobuterol
Levosalbutamol
Dihydroergocristine
Diseases
Asthma
GWAS
Chronic obstructive pulmonary disease (
30804561
)
Eosinophil percentage of white cells (
32888494
)
FEV1 (
30804560
)
Lung function (FEV1/FVC) (
30804560
)
Lymphocyte percentage of white cells (
27863252
)
Peak expiratory flow (
30804560
)
Systolic blood pressure (
29615537
)
Obstructive sleep apnea trait (average respiratory event duration) (
26977737
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Interacting Genes
160 interacting genes:
ABCA7
ADGRG1
ADRB3
AKAP12
AKAP5
ALDOA
ARF4
ARHGAP5
ARHGDIA
ARR3
ARRB1
ARRB2
ARRDC3
ARV1
ATP6V0B
ATP6V0D1
BACE1
BAZ2A
BSG
CAV3
CCKBR
CCND2
CD4
CD68
CD81
CD9
CEACAM1
CENPB
CLASP2
CLPTM1L
CNN1
CRYM
CSK
DCAF10
DCLRE1A
DNAJC14
DRD4
EGLN3
EIF2B1
FBXO17
GBP5
GJC2
GMPR2
GNA11
GNA14
GNA15
GNAI1
GNAI2
GNAS
GNAT2
GNB1
GNG2
GNL3L
GOLGB1
GPR37
GPRASP1
GPRC5B
GRB2
GRIA3
GRK1
GRK2
GRK3
GRK4
GRK5
GRK6
GTF2B
HDAC6
HNRNPK
HS2ST1
HTR4
IL1B
IL6R
INSR
KCNE1
KCNJ5
KCNJ6
KCNJ9
KCTD13
KLC1
LRATD2
MAPK8IP2
MBOAT2
MBP
MCAM
MDM2
MFSD12
MFSD2A
MGLL
MITF
MOG
MSR1
NAT14
NCOR2
NEDD4
NIPAL2
NOS1
NPTX1
OBP2A
OPRD1
PLA2G2D
PRDX1
PRKCD
PRNP
PTGDS
PTGER1
PTGES2
RAB14
RAB27A
RAB3A
RACK1
RAN
RAP2C
REL
RGR
RGS10
RGS11
RGS17
RGS2
RGS20
RGS5
RGS8
RGS9
RHOD
RIOX1
RNF41
RTN1
SACS
SENP3
SI
SLC37A1
SLC39A4
SLC52A2
SLC9A3R1
SLC9A3R2
SNCA
SNCG
SPTBN2
SRC
STAT3
STAT4
TCTA
TMCC2
TMEM144
TMEM187
TMEM259
TPTE
TSG101
TSHR
TSPAN7
UCHL1
UST
VAPA
VDAC1
VDAC2
VEGFB
WNK1
YIPF5
YWHAQ
ZNF25
ZNF254
56 interacting genes:
ADH6
ADRB1
ADRB2
AGTR1
AP2B1
ARF6
BAG1
BTK
C5AR1
CCR5
CDC42
CLTC
CSK
CXCR2
CYTH2
DVL1
DVL2
FGR
FLNA
GNB1
GNMT
GPR50
GRK2
GSK3B
HCK
HCRTR1
JUN
LIMK1
MAP2K3
MAP2K4
MAP3K5
MAPK1
MAPK10
MAPK3
MAPK9
MDM2
NEK6
NFKBIA
NSF
OPRD1
PDE4D
PIK3R2
POT1
POU2F1
PRDM16
PRKN
PTH1R
PTHLH
RALGDS
RPL15
SASH1
SLC9A5
SREBF2
STAM
TRHR
ZBTB43
Entrez ID
154
408
HPRD ID
00187
00146
Ensembl ID
ENSG00000169252
ENSG00000137486
Uniprot IDs
P07550
X5DQM5
B7Z1Q3
P49407
PDB IDs
1GQ4
2R4R
2R4S
2RH1
3D4S
3KJ6
3NY8
3NY9
3NYA
3P0G
3PDS
3SN6
4GBR
4LDE
4LDL
4LDO
4QKX
5D5A
5D5B
5D6L
5JQH
5X7D
6E67
6KR8
6MXT
6N48
6NI3
6OBA
6PRZ
6PS0
6PS1
6PS2
6PS3
6PS4
6PS5
6PS6
7BZ2
2IV8
6PWC
6TKO
6UP7
Enriched GO Terms of Interacting Partners
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