CD3G and TRA

Data Source:
HPRD (in vivo)

		CD3G	TRA
Description		CD3g molecule	T cell receptor alpha locus
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Integral Component Of Membrane Alpha-beta T Cell Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding Protein Heterodimerization Activity	Signaling Receptor Activity
	Biological Process	Adaptive Immune Response Establishment Or Maintenance Of Cell Polarity Cell Surface Receptor Signaling Pathway Protein Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Positive Thymic T Cell Selection Regulation Of Immune Response T Cell Receptor Signaling Pathway Membrane Organization Protein-containing Complex Assembly Regulation Of Lymphocyte Apoptotic Process	Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs		Muromonab
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Narcolepsy ( 24204295) Periodontal disease-related phenotype (Socransky) ( 26962152)
Interacting Genes		14 interacting genes: CD3D CD3E EMP1 KTN1 LAT MAL PMP22 TMEM19 TMEM203 TMEM262 TMEM54 TRA TRB TRD	15 interacting genes: CANX CD247 CD3D CD3G EDEM3 HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TRAT1 TRB TRD
Entrez ID		917	6955
HPRD ID		07037	01736
Ensembl ID		ENSG00000160654
Uniprot IDs		B0YIY5 P09693
PDB IDs		1SY6 6JXR
Enriched GO Terms of Interacting Partners?
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