TRA and TRAT1

Data Source:
HPRD (in vivo)

		TRA	TRAT1
Description		T cell receptor alpha locus	T cell receptor associated transmembrane adaptor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane Alpha-beta T Cell Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite T Cell Receptor Complex Mitotic Spindle
	Molecular Function	Signaling Receptor Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding
	Biological Process	Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target	Negative Regulation Of Receptor Recycling Adaptive Immune Response Cellular Defense Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Transport Positive Regulation Of Protein Kinase B Signaling
Pathways			PIP3 activates AKT signaling Downstream TCR signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Narcolepsy ( 24204295) Periodontal disease-related phenotype (Socransky) ( 26962152)	Autoimmune thyroid disease ( 32581359)
Interacting Genes		15 interacting genes: CANX CD247 CD3D CD3G EDEM3 HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TRAT1 TRB TRD	13 interacting genes: BDKRB1 CD247 CD3E FYN GRB2 LCK LCP2 LYN PIK3R1 SEC22A SRC TRA TRB
Entrez ID		6955	50852
HPRD ID		01736	05392
Ensembl ID			ENSG00000163519
Uniprot IDs			C9JF66 Q6PIZ9
PDB IDs
Enriched GO Terms of Interacting Partners?
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