TRA and CD3D

Data Source:
HPRD (in vivo, in vitro)

		TRA	CD3D
Description		T cell receptor alpha locus	CD3d molecule
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane Alpha-beta T Cell Receptor Complex	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Signaling Receptor Activity	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target	Adaptive Immune Response Cell Surface Receptor Signaling Pathway Positive Thymic T Cell Selection Regulation Of Immune Response T Cell Receptor Signaling Pathway Membrane Organization
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Muromonab Blinatumomab
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Narcolepsy ( 24204295) Periodontal disease-related phenotype (Socransky) ( 26962152)	Pulse pressure ( 27841878)
Interacting Genes		15 interacting genes: CANX CD247 CD3D CD3G EDEM3 HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TRAT1 TRB TRD	12 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 SGTB TRA TRB
Entrez ID		6955	915
HPRD ID		01736	01730
Ensembl ID			ENSG00000167286
Uniprot IDs			B0YIY4 P04234
PDB IDs			1XIW 6JXR
Enriched GO Terms of Interacting Partners?
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