RRP9 and SIRT7

Data Source:
BioGRID (enzymatic study)

		RRP9	SIRT7
Description		ribosomal RNA processing 9, U3 small nucleolar RNA binding protein	sirtuin 7
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Box C/D RNP Complex Small-subunit Processome	Chromatin Nucleus Nucleoplasm Nucleolus Nucleolus Organizer Region Cytoplasm Nuclear Speck Site Of Double-strand Break
	Molecular Function	RNA Binding Protein Binding SnoRNA Binding U3 SnoRNA Binding	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Deacetylase Activity NAD-dependent Protein Deacetylase Activity Protein-succinyllysine Desuccinylase Activity Metal Ion Binding Protein-glutaryllysine Deglutarylase Activity NAD+ Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific) Protein-propionyllysine Depropionylase Activity
	Biological Process	RRNA Processing	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Protein Deacetylation Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription Involved In Exit From Mitosis Homologous Chromosome Pairing At Meiosis RRNA Transcription Negative Regulation Of Transposition Regulation Of Mitochondrion Organization Histone Modification Negative Regulation Of Protein Ubiquitination Peptidyl-lysine Desuccinylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Export From Nucleus Protein Deglutarylation Peptidyl-lysine Deglutarylation R-loop Disassembly Histone H3 Deacetylation Histone H4 Deacetylation Protein Depropionylation Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Histone Glutamine Methylation Positive Regulation Of RRNA Processing Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Interacting Genes		4 interacting genes: CSNK2A1 RAP2A SIRT7 SMURF1	12 interacting genes: APP DDB1 FBL H2AC20 H2BC21 H3C1 H4C1 MAGED1 POLR1E RRP9 USP7 WDR77
Entrez ID		9136	51547
HPRD ID		08827	12094
Ensembl ID		ENSG00000114767	ENSG00000187531
Uniprot IDs		O43818	Q9NRC8
PDB IDs		4J0W 4JXM	5IQZ 6G0S
Enriched GO Terms of Interacting Partners?
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