PYGO2 and KAT2A

Data Source:
BioGRID (pull down)

		PYGO2	KAT2A
Description		pygopus family PHD finger 2	lysine acetyltransferase 2A
Image
GO Annotations	Cellular Component	Nucleoplasm Beta-catenin-TCF Complex	Histone Acetyltransferase Complex Extracellular Space Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Chromosome Centrosome STAGA Complex Transcription Factor TFTC Complex Oxoglutarate Dehydrogenase Complex Mitotic Spindle
	Molecular Function	Chromatin Binding Protein Binding Histone Acetyltransferase Regulator Activity Histone Binding Metal Ion Binding	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding H3 Histone Acetyltransferase Activity Protein Phosphatase Binding Histone Deacetylase Binding Histone Acetyltransferase Activity (H4-K12 Specific) Peptide-lysine-N-acetyltransferase Activity Histone Succinyltransferase Activity Histone Glutaryltransferase Activity
	Biological Process	Kidney Development Lens Development In Camera-type Eye Spermatid Nucleus Differentiation Brain Development Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Histone Acetylation Positive Regulation Of Chromatin Binding Developmental Growth Regulation Of Histone H3-K4 Methylation Roof Of Mouth Development Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly	In Utero Embryonic Development Somitogenesis Cytokine Production Neural Tube Closure Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Heart Development Long-term Memory Cell Population Proliferation Response To Organic Cyclic Compound Viral Process Histone Acetylation Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Internal Peptidyl-lysine Acetylation Telencephalon Development Metencephalon Development Midbrain Development Positive Regulation Of Cell Projection Organization Regulation Of Protein Stability Response To Nutrient Levels Positive Regulation Of Histone Acetylation Multicellular Organism Growth Histone H3 Acetylation Histone H4-K12 Acetylation Histone H3-K14 Acetylation Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Regulation Of T Cell Activation Limb Development Regulation Of Cartilage Development Cellular Response To Tumor Necrosis Factor Alpha-tubulin Acetylation Histone Succinylation Peptidyl-lysine Glutarylation Regulation Of Bone Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Stem Cell Population Maintenance Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Ub-specific processing proteases RNA Polymerase I Transcription Initiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs			Coenzyme A
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)	Coronary artery disease ( 29212778 33020668) Inflammatory bowel disease ( 26278503) Mean reticulocyte volume ( 32888494) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)
Interacting Genes		7 interacting genes: AKT1 BCL9 DCAF1 KAT2A NF2 SUPT3H TRRAP	60 interacting genes: AKT1 ATXN7 BATF2 BECN1 CCND2 CCNE1 CDK2 CDK6 CDKN2B CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL EID1 EP300 FZR1 GATA2 GRM1 H1-5 H2AC20 H2BC21 H3-4 H3C14 H4-16 H4C14 HSD11B2 IRF1 IRF2 IRF7 KDELR2 LATS2 MAP2K3 MAPK14 MYB MYC NF2 NOTCH1 PBX1 PPARG PRKDC PYGO2 RASSF1 RBPJ RELA SIRT2 STK11 TACC1 TACC2 TACC3 TADA2A TCF3 TP53 TRRAP TSC1 TTYH2 UBE2I XRCC6
Entrez ID		90780	2648
HPRD ID		06065	03807
Ensembl ID		ENSG00000163348	ENSG00000108773
Uniprot IDs		Q5T170 Q9BRQ0	Q92830
PDB IDs		2XB1 4UP0 4UP5	1F68 1Z4R 3D7C 5H84 5H86 5MLJ 5TRL 5TRM 6J3P
Enriched GO Terms of Interacting Partners?
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