PYGO2 and DCAF1

Data Source:
BioGRID (pull down)

		PYGO2	DCAF1
Description		pygopus family PHD finger 2	DDB1 and CUL4 associated factor 1
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GO Annotations	Cellular Component	Nucleoplasm Beta-catenin-TCF Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Chromatin Binding Protein Binding Histone Acetyltransferase Regulator Activity Histone Binding Metal Ion Binding	Protein Binding ATP Binding Estrogen Receptor Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Histone Kinase Activity (H2A-T120 Specific)
	Biological Process	Kidney Development Lens Development In Camera-type Eye Spermatid Nucleus Differentiation Brain Development Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Histone Acetylation Positive Regulation Of Chromatin Binding Developmental Growth Regulation Of Histone H3-K4 Methylation Roof Of Mouth Development Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Viral Process Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)	Asthma ( 32296059)
Interacting Genes		7 interacting genes: AKT1 BCL9 DCAF1 KAT2A NF2 SUPT3H TRRAP	19 interacting genes: ATM ATR CCP110 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF KATNA1 NF2 PRKDC PYGO2 RAG1 RBX1 SAMHD1 TET2 TP53 UBE2D2
Entrez ID		90780	9730
HPRD ID		06065	11674
Ensembl ID		ENSG00000163348	ENSG00000145041
Uniprot IDs		Q5T170 Q9BRQ0	Q9Y4B6
PDB IDs		2XB1 4UP0 4UP5	3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45
Enriched GO Terms of Interacting Partners?
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