PYGO2 and BCL9

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PYGO2	BCL9
Description		pygopus family PHD finger 2	BCL9 transcription coactivator
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GO Annotations	Cellular Component	Nucleoplasm Beta-catenin-TCF Complex	Nucleoplasm Cis-Golgi Network Beta-catenin-TCF Complex
	Molecular Function	Chromatin Binding Protein Binding Histone Acetyltransferase Regulator Activity Histone Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Beta-catenin Binding
	Biological Process	Kidney Development Lens Development In Camera-type Eye Spermatid Nucleus Differentiation Brain Development Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Histone Acetylation Positive Regulation Of Chromatin Binding Developmental Growth Regulation Of Histone H3-K4 Methylation Roof Of Mouth Development Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly	Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)	Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Schizophrenia (negative symptoms) ( 23382809) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 2 diabetes ( 25760438)
Interacting Genes		7 interacting genes: AKT1 BCL9 DCAF1 KAT2A NF2 SUPT3H TRRAP	4 interacting genes: CTNNB1 PYGO1 PYGO2 USP9X
Entrez ID		90780	607
HPRD ID		06065	04000
Ensembl ID		ENSG00000163348	ENSG00000116128
Uniprot IDs		Q5T170 Q9BRQ0	A0A024QYY4 O00512 Q1JQ81
PDB IDs		2XB1 4UP0 4UP5	2GL7 2VP7 2VPB 2VPD 2VPE 2VPG 3SL9
Enriched GO Terms of Interacting Partners?
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