CLDN10 and CISD2

Data Source:
BioGRID (two hybrid)

		CLDN10	CISD2
Description		claudin 10	CDGSH iron sulfur domain 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Protein-containing Complex Perinuclear Endoplasmic Reticulum
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	RNA Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Ion Transport Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Ion Transport Bicellular Tight Junction Assembly	Autophagy Of Mitochondrion Multicellular Organism Aging Regulation Of Autophagy
Pathways		Tight junction interactions
Drugs
Diseases			Wolfram syndrome (WFS); DIDMOAD syndrome
GWAS		Dental caries (decayed and filled deciduous teeth) ( 31533690) Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483) Psychosis proneness (hypomanic personality scale) ( 28525603)	Asthma and attention deficit hyperactivity disorder ( 31619474) Estimated glomerular filtration rate ( 31152163) Primary biliary cholangitis ( 26394269) Schizophrenia ( 28991256) Type 2 diabetes ( 28869590)
Interacting Genes		11 interacting genes: BEST2 CISD2 HSD17B13 HTR4 LMNA OPRM1 PEX12 REEP1 TMEM14B TMEM9 VKORC1	58 interacting genes: AIG1 APOL2 APP AQP10 BCL2L2 BET1 BMP10 BTN2A2 C14orf180 C2CD2L C4orf3 CDIPT CFHR5 CLDN10 CLN6 CYBC1 EHHADH EMD FAM241B GALNT15 GAST GPR37L1 HHATL IER3 KIR2DL3 LEPROTL1 LRP10 MAN2B2 MIP NAPB NRG4 NSG1 PGAP2 PLPP4 PLPPR2 PNKP POMGNT1 RTP2 RUSF1 SEC22A SERP2 SLC13A3 SLC35B4 SMIM1 SNORC SPP1 STX12 STX7 THSD7B TMEM187 TMEM243 TMEM43 TMEM86A TSPAN33 TTPA VAMP4 VKORC1L1 YIPF6
Entrez ID		9071	493856
HPRD ID		13063	17413
Ensembl ID		ENSG00000134873	ENSG00000145354
Uniprot IDs		P78369	Q8N5K1
PDB IDs			3FNV 4OO7 4OOA
Enriched GO Terms of Interacting Partners?
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