CISD2 and AQP10

Data Source:
BioGRID (two hybrid)

		CISD2	AQP10
Description		CDGSH iron sulfur domain 2	aquaporin 10
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Protein-containing Complex Perinuclear Endoplasmic Reticulum	Lipid Droplet Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding	Protein Binding Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity
	Biological Process	Autophagy Of Mitochondrion Multicellular Organism Aging Regulation Of Autophagy	Water Transport Response To Toxic Substance Glycerol Transport Protein Homotetramerization Cellular Response To Acidic PH Urea Transmembrane Transport
Pathways			Passive transport by Aquaporins
Drugs
Diseases		Wolfram syndrome (WFS); DIDMOAD syndrome
GWAS		Asthma and attention deficit hyperactivity disorder ( 31619474) Estimated glomerular filtration rate ( 31152163) Primary biliary cholangitis ( 26394269) Schizophrenia ( 28991256) Type 2 diabetes ( 28869590)	Bipolar disorder ( 31043756) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Non-albumin protein levels ( 29403010) Parkinson's disease progression (motor) ( 33111402) Red cell distribution width ( 32888494) Serum total protein level ( 29403010)
Interacting Genes		58 interacting genes: AIG1 APOL2 APP AQP10 BCL2L2 BET1 BMP10 BTN2A2 C14orf180 C2CD2L C4orf3 CDIPT CFHR5 CLDN10 CLN6 CYBC1 EHHADH EMD FAM241B GALNT15 GAST GPR37L1 HHATL IER3 KIR2DL3 LEPROTL1 LRP10 MAN2B2 MIP NAPB NRG4 NSG1 PGAP2 PLPP4 PLPPR2 PNKP POMGNT1 RTP2 RUSF1 SEC22A SERP2 SLC13A3 SLC35B4 SMIM1 SNORC SPP1 STX12 STX7 THSD7B TMEM187 TMEM243 TMEM43 TMEM86A TSPAN33 TTPA VAMP4 VKORC1L1 YIPF6	20 interacting genes: ARL13B CISD2 CREB3L1 CYBC1 ERGIC3 GPR152 GPR37L1 KIR2DL3 LMNA LYVE1 MGST3 NEMP1 PGRMC2 PLP1 PVR SAR1A SCN3B SSMEM1 SYT2 TMEM167B
Entrez ID		493856	89872
HPRD ID		17413	07361
Ensembl ID		ENSG00000145354	ENSG00000143595
Uniprot IDs		Q8N5K1	Q96PS8
PDB IDs		3FNV 4OO7 4OOA	6F7H
Enriched GO Terms of Interacting Partners?
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