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PIAS4 and ZNF512B
Data Source:
BioGRID
(two hybrid)
PIAS4
ZNF512B
Description
protein inhibitor of activated STAT 4
zinc finger protein 512B
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Matrix
PML Body
Transferase Complex
Nucleoplasm
Molecular Function
RNA Polymerase II Transcription Factor Binding
DNA Binding
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
SUMO Ligase Activity
DNA Binding
Protein Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Wnt Signaling Pathway
Protein Sumoylation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Sumoylation
Vitamin D Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Keratinocyte Apoptotic Process
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
Vitamin D (calciferol) metabolism
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of DNA replication proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Chronic lymphocytic leukemia (
28165464
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Birth weight (
31043758
)
Mean platelet volume (
32888494
)
Offspring birth weight (
31043758
)
Prostate cancer (
23535732
)
Interacting Genes
85 interacting genes:
ACTN1
ALDOA
AR
AREL1
BARD1
BRCA1
BTAF1
CALCOCO2
CEBPD
CHD3
CLK1
COIL
ESRRA
FTH1
GADD45G
HDAC1
HDAC2
HNF4A
HNRNPUL1
HTT
IL15RA
IMMT
IMPDH2
IRF3
IRF7
KNTC1
KPNB1
KRT18
LAMP2
LCE1D
LEF1
LRIF1
MAGEH1
MAP1LC3A
MDC1
MPRIP
NEFL
NR4A2
OAZ1
OPTN
PARP1
PDE4A
PDE4D
PDE4DIP
PHF11
PHGDH
PIAS1
PIAS2
PLAG1
PRKCZ
PRPF40A
PTN
RIF1
SATB1
SERBP1
SERPINA5
SETDB1
SH3GL3
SKIL
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
SNAI2
SNIP1
SUMO1
SUMO2
SUMO3
TADA3
TCERG1
TICAM1
TOP2A
TP53
TRIM27
TRIM32
TRIM38
UBE2I
UBE2K
VHL
VIM
ZBTB34
ZHX1
ZNF512B
ZW10
71 interacting genes:
AJUBA
ANKLE2
ANKRD28
AP1G1
APLP2
ATRX
BANP
BRD1
BTBD2
C11orf68
CDC123
CREBZF
CTBP2
DCTN1
DDX3X
DROSHA
DVL3
EHMT2
FHL3
GLRX3
GOLGA2
HEYL
HTATSF1
IL36RN
INVS
KDM2A
KDM3B
KLF10
KMT2B
L1TD1
LAMB2
LZTS2
MBD1
MDFI
MEOX2
MTUS2
MYH10
NACC1
NIBAN2
OS9
PAPPA2
PBRM1
PDE4DIP
PEG10
PIAS4
PLCG2
PPP1R15A
PTPRF
RABEP1
RPS27A
SDF4
SIAH1
SMAD1
SPTBN1
SUPT5H
TGM2
TNKS2
TOM1
TOX4
TRAF1
TRAF4
VHL
VPS35
VPS41
VWF
XPC
XRCC6
YES1
ZMYM2
ZNF143
ZYX
Entrez ID
51588
57473
HPRD ID
06910
13840
Ensembl ID
ENSG00000105229
ENSG00000196700
Uniprot IDs
B3KMR4
Q8N2W9
Q96KM6
PDB IDs
2GQJ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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