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ACVR1 and TDGF1
Data Source:
BioGRID
(pull down)
ACVR1
TDGF1
Description
activin A receptor type 1
teratocarcinoma-derived growth factor 1
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Apical Part Of Cell
Activin Receptor Complex
BMP Receptor Complex
Extracellular Region
Extracellular Space
Plasma Membrane
Cell Surface
Apical Plasma Membrane
Extrinsic Component Of Plasma Membrane
Anchored Component Of Membrane
Membrane Raft
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Activin Receptor Activity, Type I
Peptide Hormone Binding
Protein Homodimerization Activity
Cadherin Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Protein Tyrosine Kinase Binding
Signaling Receptor Binding
Protein Binding
Growth Factor Activity
Nodal Binding
Activin Receptor Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Mesoderm Formation
Neural Crest Cell Migration
Acute Inflammatory Response
Embryonic Heart Tube Morphogenesis
Outflow Tract Septum Morphogenesis
Atrioventricular Valve Morphogenesis
Mitral Valve Morphogenesis
Endocardial Cushion Morphogenesis
Endocardial Cushion Fusion
Atrial Septum Primum Morphogenesis
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
Germ Cell Development
Determination Of Left/right Symmetry
Heart Development
Dorsal/ventral Pattern Formation
Negative Regulation Of Signal Transduction
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Ossification
Positive Regulation Of Cell Migration
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Negative Regulation Of Activin Receptor Signaling Pathway
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Smooth Muscle Cell Differentiation
Pharyngeal System Development
Pathway-restricted SMAD Protein Phosphorylation
Ventricular Septum Morphogenesis
Cardiac Muscle Cell Fate Commitment
BMP Signaling Pathway Involved In Heart Development
Endocardial Cushion Cell Fate Commitment
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Determination Of Dorsal Identity
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Activation Of MAPK Activity
Blood Vessel Development
Morphogenesis Of A Branching Structure
Cell Migration Involved In Sprouting Angiogenesis
Epidermal Growth Factor Receptor Signaling Pathway
Determination Of Left/right Symmetry
Heart Development
Positive Regulation Of Cell Population Proliferation
Anterior/posterior Axis Specification, Embryo
Embryo Development Ending In Birth Or Egg Hatching
Anterior/posterior Pattern Specification
Regulation Of Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Peptidyl-serine Phosphorylation
Cell Differentiation
Positive Regulation Of Cell Migration
Mammary Gland Development
Somatic Stem Cell Population Maintenance
Cellular Response To Hepatocyte Growth Factor Stimulus
Nodal Signaling Pathway
Negative Regulation Of Apoptotic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Anatomical Structure Development
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Pathways
Signaling by NODAL
Regulation of signaling by NODAL
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
ATP
Dorsomorphin
Fostamatinib
Diseases
Fibrodysplasia ossificans progressiva (FOP)
GWAS
Severe gingival inflammation (
28459102
)
Blood protein levels (
29875488
28240269
)
Metabolite levels (
23823483
)
Refractive error (
32231278
)
Interacting Genes
70 interacting genes:
AP2B1
BAMBI
BMP2
BMP6
BMP7
BMPR1A
BMPR2
CDK14
CHN1
CREBBP
DCAF6
DUSP13
ENG
FANCL
FBXO30
FBXO7
FCHO1
FGD6
FKBP4
FNTA
GDF2
GDF5
IGSF1
IKBKB
INHBA
INHBB
INHBC
KLHL35
NEK8
NKIRAS1
NRAS
NUAK2
OTUB1
PAK1
PLEK
PLEKHB1
PLEKHJ1
RAB17
RAB25
RAB33B
RAB3B
RAB6B
RAP2A
RASD2
RASL12
RHEBL1
RHOD
RHOJ
RPS27A
RRAS2
RXRA
SMAD1
SMAD5
SMAD9
SOCS6
STIP1
STX8
TDGF1
TGFBR1
TGFBR2
THRB
TTC17
TTC27
UBA52
UBE2E3
UBXN1
USP39
VDR
VEPH1
WDR61
22 interacting genes:
ACVR1
ACVR1B
ACVR1C
ACVR2A
ACVR2B
ANG
AP2S1
BAG6
BMP4
BMP6
BMP7
BMPR1A
BMPR2
COPS6
FARSA
FBLN1
GDF3
GDF9
INHBB
LRIF1
NODAL
TGFBR2
Entrez ID
90
6997
HPRD ID
00021
01757
Ensembl ID
ENSG00000115170
ENSG00000241186
Uniprot IDs
D3DPA4
Q04771
F5H1T8
P13385
PDB IDs
3H9R
3MTF
3OOM
3Q4U
4BGG
4C02
4DYM
5OXG
5OY6
6ACR
6EIX
6GI6
6GIN
6GIP
6I1S
6JUX
6SRH
6SZM
6T6D
6T8N
6TN8
6Z36
6ZGC
7A21
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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