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ACVR1 and FBXO7
Data Source:
BioGRID
(enzymatic study)
ACVR1
FBXO7
Description
activin A receptor type 1
F-box protein 7
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Apical Part Of Cell
Activin Receptor Complex
BMP Receptor Complex
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
SCF Ubiquitin Ligase Complex
Protein-containing Complex
Glial Cytoplasmic Inclusion
Classical Lewy Body
Lewy Neurite
Lewy Body Core
Lewy Body Corona
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Activin Receptor Activity, Type I
Peptide Hormone Binding
Protein Homodimerization Activity
Cadherin Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Protein Tyrosine Kinase Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Protein Heterodimerization Activity
Ubiquitin Ligase-substrate Adaptor Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Mesoderm Formation
Neural Crest Cell Migration
Acute Inflammatory Response
Embryonic Heart Tube Morphogenesis
Outflow Tract Septum Morphogenesis
Atrioventricular Valve Morphogenesis
Mitral Valve Morphogenesis
Endocardial Cushion Morphogenesis
Endocardial Cushion Fusion
Atrial Septum Primum Morphogenesis
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
Germ Cell Development
Determination Of Left/right Symmetry
Heart Development
Dorsal/ventral Pattern Formation
Negative Regulation Of Signal Transduction
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Ossification
Positive Regulation Of Cell Migration
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Negative Regulation Of Activin Receptor Signaling Pathway
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Smooth Muscle Cell Differentiation
Pharyngeal System Development
Pathway-restricted SMAD Protein Phosphorylation
Ventricular Septum Morphogenesis
Cardiac Muscle Cell Fate Commitment
BMP Signaling Pathway Involved In Heart Development
Endocardial Cushion Cell Fate Commitment
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Determination Of Dorsal Identity
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Protein Polyubiquitination
Autophagy Of Mitochondrion
Ubiquitin-dependent Protein Catabolic Process
Protein Targeting To Mitochondrion
Regulation Of Neuron Projection Development
Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Locomotion
Post-translational Protein Modification
Negative Regulation Of Lymphocyte Differentiation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Oxidative Stress-induced Neuron Death
Positive Regulation Of Autophagy Of Mitochondrion
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
ATP
Dorsomorphin
Fostamatinib
Diseases
Fibrodysplasia ossificans progressiva (FOP)
Parkinson's disease (PD)
GWAS
Severe gingival inflammation (
28459102
)
Blood protein levels (
29875488
)
Mean corpuscular hemoglobin (
29403010
32888494
27863252
)
Mean corpuscular volume (
29403010
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
27863252
)
Red blood cell traits (
23222517
)
Red cell distribution width (
32888494
27863252
)
Refractive error (
32231278
)
Interacting Genes
70 interacting genes:
AP2B1
BAMBI
BMP2
BMP6
BMP7
BMPR1A
BMPR2
CDK14
CHN1
CREBBP
DCAF6
DUSP13
ENG
FANCL
FBXO30
FBXO7
FCHO1
FGD6
FKBP4
FNTA
GDF2
GDF5
IGSF1
IKBKB
INHBA
INHBB
INHBC
KLHL35
NEK8
NKIRAS1
NRAS
NUAK2
OTUB1
PAK1
PLEK
PLEKHB1
PLEKHJ1
RAB17
RAB25
RAB33B
RAB3B
RAB6B
RAP2A
RASD2
RASL12
RHEBL1
RHOD
RHOJ
RPS27A
RRAS2
RXRA
SMAD1
SMAD5
SMAD9
SOCS6
STIP1
STX8
TDGF1
TGFBR1
TGFBR2
THRB
TTC17
TTC27
UBA52
UBE2E3
UBXN1
USP39
VDR
VEPH1
WDR61
345 interacting genes:
AATF
ABCF3
ABL1
ACOT8
ACSL5
ACSM3
ACTC1
ACVR1
ACVR2B
AK8
AKAP14
AKIRIN2
AKT3
ALKBH3
AMOTL2
ANGPTL7
ANKRD36BP1
ANP32E
APEX1
APOBEC3C
APOBEC4
ASPH
ASPHD1
ATAT1
ATF5
ATP5F1C
BAG3
BCKDK
BIRC2
BLK
BUB1
BUB1B
C11orf16
C15orf48
C1orf105
C1orf115
C22orf31
C2orf88
CACYBP
CAMK1
CAPN5
CASQ2
CCBE1
CCDC186
CCDC60
CCDC88C
CCNE2
CDC34
CDK10
CDK14
CENPJ
CEP112
CFAP300
CHCHD2
CHCHD6
CHMP2B
CHMP3
CILK1
CIRBP
CKAP2
CLHC1
CLIP3
CMTR2
CNOT7
COLEC12
CPEB4
CSNK1E
CXCL12
CXCL9
DDRGK1
DDX10
DHRS2
DHX40
DNAH14
DNAJA3
DNAJB12
DNAJC30
DPY19L2P1
DRAP1
ELF4
EP400P1
EPHA3
EPHB2
EPHB3
EPHB4
ERBB2
ERICH2
FGF10
FGF13
FGFR1
FGFR2
FMOD
FUT8
FYTTD1
GADD45GIP1
GAPDH
GBP2
GEMIN2
GGA2
GLCE
GLIPR2
GLRX2
GMCL2
GNLY
GORAB
GPAM
GPKOW
GRK6
GSK3B
H1-0
H2AZ2
H3-3B
HADH
HMG20A
HMG20B
HMGB2
HMGCS2
HNRNPK
HPF1
IDH2
IFT88
IGKV1-5
IL4
IL7
ILKAP
INKA2
INPP5K
INTS7
IPO9
IRF3
JADE2
KCNAB1
KCTD14
KHDRBS3
KIAA1586
KIF12
KIFC3
KIRREL3-AS3
KLF4
KMO
KPNA5
LETMD1
LGALS3BP
LIMK1
LIMK2
LINC01483
LMNA
LRRC20
LRRC8E
LRRFIP1
MAK
MAP2K6
MAPK10
MAPK9
MAPRE2
MARK2
MARK3
MBD5
MBNL1
MCM2
MCM5
MDK
MED22
MED27
MEF2D
MEST
MIR1-1HG-AS1
MIS18BP1
MITF
MMP13
MMP8
MNDA
MOB3A
MOB3C
MPG
MPP3
MPZL1
MRM3
MRPL27
MRPS14
MTIF3
MTUS1
MYOG
NANS
NDE1
NFIA
NFIC
NKD2
NPHP1
NUDT16L1
NUMB
NVL
ODF2L
OLFML2A
OR14K1
ORC3
OSTF1
PABPC3
PACRG
PAFAH1B1
PAK6
PCBD2
PDCD7
PDE12
PDE4D
PDGFB
PGAP4
PHLDA1
PIEZO1
PIGY
PIM1
PIM2
PINK1
PLEKHA1
PNOC
PNRC2
POLDIP2
POLR2K
PPHLN1
PPP1CB
PPP1R17
PPP1R21
PRAME
PRICKLE2
PRKACB
PRKCA
PRKCB
PRKCG
PRKN
PRMT1
PRRC2B
PUF60
PUSL1
QKI
RBBP6
RBM23
RBM33
RCC1
REEP3
REEP4
RET
RGS1
RGS22
RNF121
RNF20
RORB
RPL14
RPL26
RPL36A
RPL37A
RPL3L
RPL6
RPS15A
RPS18
RPS19BP1
RPS2
RPS6KA3
RPS6KB1
RSL24D1
RWDD4
S100A13
S100A16
S100B
SAMHD1
SCARA5
SDCCAG8
SEC16B
SEC24C
SET
SFR1
SHMT1
SHMT2
SKP1
SLAIN1
SLC25A26
SLC35B3
SLC7A6OS
SMARCD1
SMOC2
SNAP25
SNRPA
SNX33
SPATA4
SPDYA
SPRY2
SRCIN1
SRPK3
SRSF10
SRSF7
SS18L2
STAT6
STYX
TAF9B
TARDBP
TBC1D3P2
TBPL1
TC2N
TCP10L3
TEAD4
TEC
TECR
TECRL
TENT5D
TEX29
TGIF2
THAP7
TLE3
TMED10
TMEM120A
TMEM237
TMOD2
TMPRSS5
TOMM20
TRAPPC12
TRIB3
TRIM44
TSBP1
TSLP
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2J2
UBE2M
UROD
USF1
USH1C
UXS1
UXT
VPS16
VRK3
WDR18
WDR24
XPO1
XRN1
YPEL5
ZBTB44
ZC2HC1C
ZFYVE21
ZKSCAN8
ZMYM5
ZNF462
ZNF574
ZNF684
ZNF688
Entrez ID
90
25793
HPRD ID
00021
07292
Ensembl ID
ENSG00000115170
ENSG00000100225
Uniprot IDs
D3DPA4
Q04771
Q9Y3I1
PDB IDs
3H9R
3MTF
3OOM
3Q4U
4BGG
4C02
4DYM
5OXG
5OY6
6ACR
6EIX
6GI6
6GIN
6GIP
6I1S
6JUX
6SRH
6SZM
6T6D
6T8N
6TN8
6Z36
6ZGC
7A21
4L9C
4L9H
Enriched GO Terms of Interacting Partners
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