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ACVR1 and INHBA
Data Source:
HPRD
(in vivo)
ACVR1
INHBA
Description
activin A receptor type 1
inhibin subunit beta A
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Apical Part Of Cell
Activin Receptor Complex
BMP Receptor Complex
Extracellular Region
Extracellular Space
Activin A Complex
Inhibin A Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Activin Receptor Activity, Type I
Peptide Hormone Binding
Protein Homodimerization Activity
Cadherin Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Protein Tyrosine Kinase Binding
Cytokine Activity
Hormone Activity
Protein Binding
Growth Factor Activity
Peptide Hormone Binding
Inhibin Binding
Identical Protein Binding
Protein-containing Complex Binding
Type II Activin Receptor Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Mesoderm Formation
Neural Crest Cell Migration
Acute Inflammatory Response
Embryonic Heart Tube Morphogenesis
Outflow Tract Septum Morphogenesis
Atrioventricular Valve Morphogenesis
Mitral Valve Morphogenesis
Endocardial Cushion Morphogenesis
Endocardial Cushion Fusion
Atrial Septum Primum Morphogenesis
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
Germ Cell Development
Determination Of Left/right Symmetry
Heart Development
Dorsal/ventral Pattern Formation
Negative Regulation Of Signal Transduction
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Ossification
Positive Regulation Of Cell Migration
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Negative Regulation Of Activin Receptor Signaling Pathway
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Smooth Muscle Cell Differentiation
Pharyngeal System Development
Pathway-restricted SMAD Protein Phosphorylation
Ventricular Septum Morphogenesis
Cardiac Muscle Cell Fate Commitment
BMP Signaling Pathway Involved In Heart Development
Endocardial Cushion Cell Fate Commitment
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Determination Of Dorsal Identity
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Ovarian Follicle Development
Hair Follicle Development
Hematopoietic Progenitor Cell Differentiation
Regulation Of Transcription By RNA Polymerase II
Defense Response
Cell Cycle Arrest
Cell Surface Receptor Signaling Pathway
Cell-cell Signaling
Nervous System Development
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Response To Wounding
Positive Regulation Of Gene Expression
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Striatal Medium Spiny Neuron Differentiation
Cell Differentiation
Erythrocyte Differentiation
Negative Regulation Of Cell Growth
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Interferon-gamma Production
Activin Receptor Signaling Pathway
Endodermal Cell Differentiation
Negative Regulation Of Phosphorylation
Odontogenesis
Response To Drug
Hemoglobin Biosynthetic Process
Progesterone Secretion
Negative Regulation Of B Cell Differentiation
Positive Regulation Of Erythrocyte Differentiation
Negative Regulation Of Macrophage Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Follicle-stimulating Hormone Secretion
Positive Regulation Of Follicle-stimulating Hormone Secretion
Negative Regulation Of Follicle-stimulating Hormone Secretion
Mesodermal Cell Differentiation
Roof Of Mouth Development
Positive Regulation Of Ovulation
SMAD Protein Signal Transduction
Eyelid Development In Camera-type Eye
Cellular Response To Follicle-stimulating Hormone Stimulus
Cellular Response To Cholesterol
GABAergic Neuron Differentiation
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Signaling by Activin
Signaling by Activin
Glycoprotein hormones
Antagonism of Activin by Follistatin
Drugs
ATP
Dorsomorphin
Fostamatinib
Diseases
Fibrodysplasia ossificans progressiva (FOP)
GWAS
Severe gingival inflammation (
28459102
)
Asthma (
29273806
)
Cortisol levels (saliva) (
28843169
)
Menarche (age at onset) (
27182965
21102462
25231870
)
Parent of origin effect on language impairment (paternal) (
24571439
)
Pit-and-Fissure caries (
23470693
)
Interacting Genes
70 interacting genes:
AP2B1
BAMBI
BMP2
BMP6
BMP7
BMPR1A
BMPR2
CDK14
CHN1
CREBBP
DCAF6
DUSP13
ENG
FANCL
FBXO30
FBXO7
FCHO1
FGD6
FKBP4
FNTA
GDF2
GDF5
IGSF1
IKBKB
INHBA
INHBB
INHBC
KLHL35
NEK8
NKIRAS1
NRAS
NUAK2
OTUB1
PAK1
PLEK
PLEKHB1
PLEKHJ1
RAB17
RAB25
RAB33B
RAB3B
RAB6B
RAP2A
RASD2
RASL12
RHEBL1
RHOD
RHOJ
RPS27A
RRAS2
RXRA
SMAD1
SMAD5
SMAD9
SOCS6
STIP1
STX8
TDGF1
TGFBR1
TGFBR2
THRB
TTC17
TTC27
UBA52
UBE2E3
UBXN1
USP39
VDR
VEPH1
WDR61
13 interacting genes:
ACVR1
ACVR1B
ACVR2A
ACVR2B
CHRDL2
ENG
FST
FSTL3
IGFBP7
INHA
INHBB
INHBC
TGFBR3
Entrez ID
90
3624
HPRD ID
00021
00929
Ensembl ID
ENSG00000115170
ENSG00000122641
Uniprot IDs
D3DPA4
Q04771
A4D1W7
P08476
PDB IDs
3H9R
3MTF
3OOM
3Q4U
4BGG
4C02
4DYM
5OXG
5OY6
6ACR
6EIX
6GI6
6GIN
6GIP
6I1S
6JUX
6SRH
6SZM
6T6D
6T8N
6TN8
6Z36
6ZGC
7A21
1NYS
1NYU
1S4Y
2ARP
2ARV
2B0U
2P6A
3B4V
4MID
5HLY
5HLZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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