KALRN and CACNA1A

Data Source:
BioGRID (two hybrid)

		KALRN	CACNA1A
Description		kalirin RhoGEF kinase	calcium voltage-gated channel subunit alpha1 A
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Actin Cytoskeleton Extracellular Exosome	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Cell Projection Neuronal Cell Body Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Amyloid-beta Binding Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Axon Guidance Central Nervous System Development Neuromuscular Junction Development Lactation Memory Adult Locomotory Behavior Vesicle-mediated Transport Social Behavior Intracellular Signal Transduction Maternal Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Habituation Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Growth Hormone Secretion Maternal Process Involved In Parturition Positive Regulation Of Dendritic Spine Morphogenesis	Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Cell Death Regulation Of Ion Transmembrane Transport Regulation Of Insulin Secretion Modulation Of Chemical Synaptic Transmission Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Response To Amyloid-beta Cellular Response To Amyloid-beta
Pathways		NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling G alpha (q) signalling events G alpha (12/13) signalling events MAPK6/MAPK4 signaling	Presynaptic depolarization and calcium channel opening Regulation of insulin secretion
Drugs			Ergocalciferol Enflurane Phenytoin Spironolactone Magnesium sulfate Verapamil Levomenthol Loperamide Bepridil Ziconotide Dotarizine Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases			Episodic ataxias Familial or sporadic hemiplegic migraine Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Acute graft versus host disease in bone marrow transplantation (donor effect) ( 27595289) Amyotrophic lateral sclerosis ( 26580837) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Diffuse large B-cell lymphoma or systemic lupus erythematosus ( 31407831) General cognitive ability ( 29844566) Hematocrit ( 32888494) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 29617998 29785010 31959993) Longevity (age >99th survival percentile) ( 31413261) Low urine pH ( 30476138) Lymphocyte counts ( 32888494) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Mean platelet volume ( 22139419 32888494 27863252) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Red cell distribution width ( 32888494) Schizophrenia ( 30285260) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Thyroid peroxidase antibody levels ( 24586183) Urine pH measurement ( 30476138)	Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		16 interacting genes: ATXN7 CACNA1A CDC5L COIL DISC1 DTNBP1 ENO3 EPHB2 FASLG GFI1B LNX1 NDEL1 PAM SPTAN1 SUMO2 SUMO3	92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233
Entrez ID		8997	773
HPRD ID		06859	03004
Ensembl ID		ENSG00000160145	ENSG00000141837
Uniprot IDs		C9IZQ6 O60229	A0A087WW63 B5TYJ1 O00555 Q9NS89
PDB IDs		5QQD 5QQE 5QQF 5QQG 5QQH 5QQI 5QQJ 5QQK 5QQL 5QQM 5QQN 5QU9	3BXK
Enriched GO Terms of Interacting Partners?
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