CACNA1A and GRN

Data Source:
BioGRID (two hybrid)

		CACNA1A	GRN
Description		calcium voltage-gated channel subunit alpha1 A	granulin precursor
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Cell Projection Neuronal Cell Body Synapse	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Chaperone Binding
	Biological Process	Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Cell Death Regulation Of Ion Transmembrane Transport Regulation Of Insulin Secretion Modulation Of Chemical Synaptic Transmission Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Response To Amyloid-beta Cellular Response To Amyloid-beta	Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Protein Stabilization Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Aspartic-type Peptidase Activity Positive Regulation Of Lysosome Organization
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion	Neutrophil degranulation
Drugs		Ergocalciferol Enflurane Phenytoin Spironolactone Magnesium sulfate Verapamil Levomenthol Loperamide Bepridil Ziconotide Dotarizine Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases		Episodic ataxias Familial or sporadic hemiplegic migraine Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)	Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Intracranial volume ( 22504418) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)
Interacting Genes		92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233	79 interacting genes: ARFGAP1 ATN1 ATXN7 C22orf39 C4orf17 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CLPP CRCT1 CRKL CRY1 CXCL5 CYSRT1 DLK1 DLX2 DMRT3 ECM1 ELANE FAM131C FAM76B FANCL FRAT1 GFI1B GLRX3 GNE HK3 HOXA1 HSPG2 KRT18 KRT34 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP5-9 KRTAP6-1 KRTAP6-2 LCE1A LCE1D LCE1E LCE2B LCE2D LCE3C LCE3E LCE4A MEOX2 NLK NUFIP2 OTX1 P4HB PIK3R2 PLLP POT1 POU4F2 PRKAB2 PTPMT1 RAC1 SGTA SLC13A1 SLPI SMAD9 SMCP SPRY2 TAT TGM2 TLE5 TOP3B TSPAN4 UTP23 VASN YY1
Entrez ID		773	2896
HPRD ID		03004	00733
Ensembl ID		ENSG00000141837	ENSG00000030582
Uniprot IDs		A0A087WW63 B5TYJ1 O00555 Q9NS89	P28799
PDB IDs		3BXK	1G26 2JYE 2JYT 2JYU 2JYV 6NUG
Enriched GO Terms of Interacting Partners?
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