CACNA1A and MEGF8

Data Source:
BioGRID (two hybrid)

		CACNA1A	MEGF8
Description		calcium voltage-gated channel subunit alpha1 A	multiple EGF like domains 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Cell Projection Neuronal Cell Body Synapse	Nucleus Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding	Calcium Ion Binding Protein Binding
	Biological Process	Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Cell Death Regulation Of Ion Transmembrane Transport Regulation Of Insulin Secretion Modulation Of Chemical Synaptic Transmission Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Response To Amyloid-beta Cellular Response To Amyloid-beta	Embryonic Heart Tube Morphogenesis Animal Organ Morphogenesis Tissue Development Regulation Of Gene Expression Embryonic Limb Morphogenesis BMP Signaling Pathway Limb Morphogenesis Cell Migration Involved In Gastrulation Negative Regulation Of Smoothened Signaling Pathway Embryonic Skeletal System Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Epiboly Involved In Gastrulation With Mouth Forming Second Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Coronary Vasculature Development Determination Of Heart Left/right Asymmetry Determination Of Digestive Tract Left/right Asymmetry Craniofacial Suture Morphogenesis Fasciculation Of Sensory Neuron Axon
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion
Drugs		Ergocalciferol Enflurane Phenytoin Spironolactone Magnesium sulfate Verapamil Levomenthol Loperamide Bepridil Ziconotide Dotarizine Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases		Episodic ataxias Familial or sporadic hemiplegic migraine Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233	3 interacting genes: ATN1 CACNA1A GFI1B
Entrez ID		773	1954
HPRD ID		03004	10370
Ensembl ID		ENSG00000141837	ENSG00000105429
Uniprot IDs		A0A087WW63 B5TYJ1 O00555 Q9NS89	Q7Z7M0
PDB IDs		3BXK
Enriched GO Terms of Interacting Partners?
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