KALRN and GFI1B

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KALRN	GFI1B
Description		kalirin RhoGEF kinase	growth factor independent 1B transcriptional repressor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Actin Cytoskeleton Extracellular Exosome	Nucleus Nucleoplasm Transcription Regulator Complex Plasma Membrane Nuclear Matrix
	Molecular Function	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Phosphorylation Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Axon Guidance Central Nervous System Development Neuromuscular Junction Development Lactation Memory Adult Locomotory Behavior Vesicle-mediated Transport Social Behavior Intracellular Signal Transduction Maternal Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Habituation Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Growth Hormone Secretion Maternal Process Involved In Parturition Positive Regulation Of Dendritic Spine Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Hemopoiesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling G alpha (q) signalling events G alpha (12/13) signalling events MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Acute graft versus host disease in bone marrow transplantation (donor effect) ( 27595289) Amyotrophic lateral sclerosis ( 26580837) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Diffuse large B-cell lymphoma or systemic lupus erythematosus ( 31407831) General cognitive ability ( 29844566) Hematocrit ( 32888494) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 29617998 29785010 31959993) Longevity (age >99th survival percentile) ( 31413261) Low urine pH ( 30476138) Lymphocyte counts ( 32888494) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Mean platelet volume ( 22139419 32888494 27863252) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Red cell distribution width ( 32888494) Schizophrenia ( 30285260) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Thyroid peroxidase antibody levels ( 24586183) Urine pH measurement ( 30476138)	Basophil percentage of white cells ( 27863252) Cardiometabolic and hematological traits ( 27668658) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		16 interacting genes: ATXN7 CACNA1A CDC5L COIL DISC1 DTNBP1 ENO3 EPHB2 FASLG GFI1B LNX1 NDEL1 PAM SPTAN1 SUMO2 SUMO3	71 interacting genes: ACTN1 AGRN AJUBA ANKS3 ATXN2 BABAM2 BECN1 BEGAIN BEND5 BRCA1 CCDC136 CCDC85B CENPB CENPJ COPS5 DNAJA3 DTNA DZANK1 EFEMP1 EFEMP2 EGFL7 FBLN1 FBLN5 GPAT4 GRIP2 GRN HECW1 HGS HNRNPK HSPG2 IFFO1 JAG2 KALRN KIF17 LAMB1 LTBP4 LZTS2 MATR3 MEGF6 MEGF8 MID2 MON1A MYH14 NELL1 NELL2 NOTCH1 NSMF PDE4DIP PDLIM5 PDZD4 PHC2 PICK1 POLR1H PSMA3 RAB11FIP4 RCHY1 RINT1 RNF31 RUNDC3A TAF1 TLE5 TMF1 TNS2 TRAF1 TRIM27 TRIP6 TSPYL2 TXNDC11 USHBP1 VSNL1 ZNRF3
Entrez ID		8997	8328
HPRD ID		06859	05088
Ensembl ID		ENSG00000160145	ENSG00000165702
Uniprot IDs		C9IZQ6 O60229	A0A024R8F3 Q5VTD9
PDB IDs		5QQD 5QQE 5QQF 5QQG 5QQH 5QQI 5QQJ 5QQK 5QQL 5QQM 5QQN 5QU9
Enriched GO Terms of Interacting Partners?
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