CACNA1A and SCP2

Data Source:
BioGRID (two hybrid)

		CACNA1A	SCP2
Description		calcium voltage-gated channel subunit alpha1 A	sterol carrier protein 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Cell Projection Neuronal Cell Body Synapse	Nucleoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Amyloid-beta Binding Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding	Fatty-acyl-CoA Binding Acetyl-CoA C-acyltransferase Activity Signaling Receptor Binding Protein Binding Cholesterol Binding Sterol Binding Propanoyl-CoA C-acyltransferase Activity Long-chain Fatty Acyl-CoA Binding Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Acetyl-CoA C-myristoyltransferase Activity Oleic Acid Binding
	Biological Process	Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Cell Death Regulation Of Ion Transmembrane Transport Regulation Of Insulin Secretion Modulation Of Chemical Synaptic Transmission Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Response To Amyloid-beta Cellular Response To Amyloid-beta	Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Steroid Biosynthetic Process Bile Acid Biosynthetic Process Bile Acid Metabolic Process Phospholipid Transport Positive Regulation Of Intracellular Cholesterol Transport Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Lipid Hydroperoxide Transport
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion	alpha-linolenic acid (ALA) metabolism Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		Ergocalciferol Enflurane Phenytoin Spironolactone Magnesium sulfate Verapamil Levomenthol Loperamide Bepridil Ziconotide Dotarizine Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases		Episodic ataxias Familial or sporadic hemiplegic migraine Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia Leukoencephalopathy with dystonia and motor neuropathy
GWAS		Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233	9 interacting genes: ACAA2 ACOX1 CACNA1A CAV1 CREB3 EHHADH PEX5 PITPNA TRIP13
Entrez ID		773	6342
HPRD ID		03004	01700
Ensembl ID		ENSG00000141837	ENSG00000116171
Uniprot IDs		A0A087WW63 B5TYJ1 O00555 Q9NS89	A0A384NY87 B2R761 E9PLD1 P22307 Q59HG9
PDB IDs		3BXK	1QND 2C0L
Enriched GO Terms of Interacting Partners?
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