KALRN and ENO3

Data Source:
BioGRID (two hybrid)

		KALRN	ENO3
Description		kalirin RhoGEF kinase	enolase 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Actin Cytoskeleton Extracellular Exosome	Phosphopyruvate Hydratase Complex Extracellular Space Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Protein Phosphorylation Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Axon Guidance Central Nervous System Development Neuromuscular Junction Development Lactation Memory Adult Locomotory Behavior Vesicle-mediated Transport Social Behavior Intracellular Signal Transduction Maternal Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Habituation Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Growth Hormone Secretion Maternal Process Involved In Parturition Positive Regulation Of Dendritic Spine Morphogenesis	Gluconeogenesis Glycolytic Process Aging Regulation Of Vacuole Fusion, Non-autophagic Response To Drug Skeletal Muscle Tissue Regeneration Canonical Glycolysis
Pathways		NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling G alpha (q) signalling events G alpha (12/13) signalling events MAPK6/MAPK4 signaling	Glycolysis Gluconeogenesis
Drugs			2-phospho-D-glyceric acid Phosphoenolpyruvate 2-Phosphoglycolic Acid Phosphonoacetohydroxamic Acid
Diseases
GWAS		Acute graft versus host disease in bone marrow transplantation (donor effect) ( 27595289) Amyotrophic lateral sclerosis ( 26580837) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Diffuse large B-cell lymphoma or systemic lupus erythematosus ( 31407831) General cognitive ability ( 29844566) Hematocrit ( 32888494) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 29617998 29785010 31959993) Longevity (age >99th survival percentile) ( 31413261) Low urine pH ( 30476138) Lymphocyte counts ( 32888494) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Mean platelet volume ( 22139419 32888494 27863252) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Red cell distribution width ( 32888494) Schizophrenia ( 30285260) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Thyroid peroxidase antibody levels ( 24586183) Urine pH measurement ( 30476138)	Red cell distribution width ( 32888494)
Interacting Genes		16 interacting genes: ATXN7 CACNA1A CDC5L COIL DISC1 DTNBP1 ENO3 EPHB2 FASLG GFI1B LNX1 NDEL1 PAM SPTAN1 SUMO2 SUMO3	20 interacting genes: ALDOA APP DCTN1 DSP HSPB2 KALRN LINC01554 MAN2A2 MTMR14 NEB PGM1 PKM PNKD SGCG SNAPIN SPTB TCAP TRAPPC2 TRIM63 TTN
Entrez ID		8997	2027
HPRD ID		06859	11746
Ensembl ID		ENSG00000160145	ENSG00000108515
Uniprot IDs		C9IZQ6 O60229	P13929
PDB IDs		5QQD 5QQE 5QQF 5QQG 5QQH 5QQI 5QQJ 5QQK 5QQL 5QQM 5QQN 5QU9	2XSX
Enriched GO Terms of Interacting Partners?
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