LHX4 and PARP11

Data Source:
BioGRID (two hybrid)

		LHX4	PARP11
Description		LIM homeobox 4	poly(ADP-ribose) polymerase family member 11
Image
GO Annotations	Cellular Component	Chromatin Nucleus	Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Nuclear Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	NAD+ ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity
	Biological Process	Placenta Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Nuclear Envelope Organization Spermatogenesis Protein Transport Cell Differentiation MRNA Transport Protein Auto-ADP-ribosylation Protein Mono-ADP-ribosylation
Pathways		Regulation of expression of SLITs and ROBOs
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Refractive error ( 32231278)	Cognitive performance ( 20125193) Colorectal cancer ( 23263487) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Fasting insulin (dietary factor interaction) ( 24204828) Hematocrit ( 29403010) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Pulse pressure ( 27841878) Red blood cell count ( 29403010) Total hippocampal volume ( 30279459) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		53 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB1 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 YY1 ZBTB2 ZNF354C ZNF76	7 interacting genes: DTX3 GTPBP3 HOOK2 LHX3 LHX4 MDFI TRIP13
Entrez ID		89884	57097
HPRD ID		03686	15101
Ensembl ID		ENSG00000121454	ENSG00000111224
Uniprot IDs		A0A0S2Z5S4 Q969G2	Q9NR21
PDB IDs		5HOD	2DK6
Enriched GO Terms of Interacting Partners?
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