LHX4 and TRMT11

Data Source:
BioGRID (two hybrid)

		LHX4	TRMT11
Description		LIM homeobox 4	tRNA methyltransferase 11 homolog
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	TRNA Binding TRNA (guanine-N2-)-methyltransferase Activity Protein Binding Methyltransferase Activity
	Biological Process	Placenta Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	TRNA Methylation
Pathways		Regulation of expression of SLITs and ROBOs	tRNA modification in the nucleus and cytosol
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Refractive error ( 32231278)	Behavioural changes in frontotemporal lobe dementia ( 29724592) Heel bone mineral density ( 30598549) Male-pattern baldness ( 28196072) Menarche (age at onset) ( 21102462) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603)
Interacting Genes		53 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB1 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 YY1 ZBTB2 ZNF354C ZNF76	1 interacting genes: LHX4
Entrez ID		89884	60487
HPRD ID		03686	12898
Ensembl ID		ENSG00000121454	ENSG00000066651
Uniprot IDs		A0A0S2Z5S4 Q969G2	Q7Z4G4
PDB IDs		5HOD
Enriched GO Terms of Interacting Partners?
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