PARP11 and HOOK2

Data Source:
BioGRID (two hybrid)

		PARP11	HOOK2
Description		poly(ADP-ribose) polymerase family member 11	hook microtubule tethering protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Nuclear Body	Cytoplasm Centrosome Cytosol Microtubule HOPS Complex Intracellular Membrane-bounded Organelle FHF Complex
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding
	Biological Process	Nuclear Envelope Organization Spermatogenesis Protein Transport Cell Differentiation MRNA Transport Protein Auto-ADP-ribosylation Protein Mono-ADP-ribosylation	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport
Pathways
Drugs
Diseases
GWAS		Cognitive performance ( 20125193) Colorectal cancer ( 23263487) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Fasting insulin (dietary factor interaction) ( 24204828) Hematocrit ( 29403010) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Pulse pressure ( 27841878) Red blood cell count ( 29403010) Total hippocampal volume ( 30279459) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Platelet distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		7 interacting genes: DTX3 GTPBP3 HOOK2 LHX3 LHX4 MDFI TRIP13	121 interacting genes: ABLIM1 AKTIP ANKRD11 ANKRD36BP1 AP1M1 APEX2 ATG5 BYSL C1orf109 CABP2 CBX8 CCDC187 CCDC198 CCDC33 CDK18 CDKN1A CEP95 CWF19L2 CYTH4 DCX DDX6 DUSP13 EIF3D ENKD1 EPS8 FAM107A FAM110A FAM161A FAM161B FAM50B FAM90A1 FGF16 FLYWCH1 GAS2L2 GEM GPKOW HAUS1 HDAC4 HOOK1 HOOK3 HOXB5 IL16 IPP IQCE ITSN2 KANSL1 KAT7 KIAA0408 KIF9 KLK15 KRT1 LENG1 LNX1 LRGUK MCM10 MCRS1 MFAP1 MORN3 MPPED2 MYLIP NEK6 OAS1 PARP11 PIMREG PKP1 PKP2 PPP1R18 PPP1R26 PRPF18 PRPF31 PRR35 PSMA1 PSMF1 RABGEF1 RALBP1 RBM41 RCOR3 RGS8 RIBC2 RITA1 RNF169 RNF6 SCNM1 SH2D4A SMARCB1 SNW1 SPATC1L SUV39H1 SYT17 SYT6 TBC1D22B TBC1D30 TCEANC TCHP TPM3 TSGA10 TSGA10IP TTC23 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZFP1 ZFYVE26 ZGPAT ZNF107 ZNF250 ZNF35 ZNF417 ZNF48 ZNF497 ZNF572 ZNF587 ZNF638 ZNF648 ZNF835 ZNF844
Entrez ID		57097	29911
HPRD ID		15101	09698
Ensembl ID		ENSG00000111224	ENSG00000095066
Uniprot IDs		Q9NR21	Q96ED9
PDB IDs		2DK6
Enriched GO Terms of Interacting Partners?
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