PARP11 and LHX4

Data Source:
BioGRID (two hybrid)

		PARP11	LHX4
Description		poly(ADP-ribose) polymerase family member 11	LIM homeobox 4
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GO Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Nuclear Body	Chromatin Nucleus
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nuclear Envelope Organization Spermatogenesis Protein Transport Cell Differentiation MRNA Transport Protein Auto-ADP-ribosylation Protein Mono-ADP-ribosylation	Placenta Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Cognitive performance ( 20125193) Colorectal cancer ( 23263487) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Fasting insulin (dietary factor interaction) ( 24204828) Hematocrit ( 29403010) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Pulse pressure ( 27841878) Red blood cell count ( 29403010) Total hippocampal volume ( 30279459) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)	Refractive error ( 32231278)
Interacting Genes		7 interacting genes: DTX3 GTPBP3 HOOK2 LHX3 LHX4 MDFI TRIP13	53 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB1 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 YY1 ZBTB2 ZNF354C ZNF76
Entrez ID		57097	89884
HPRD ID		15101	03686
Ensembl ID		ENSG00000111224	ENSG00000121454
Uniprot IDs		Q9NR21	A0A0S2Z5S4 Q969G2
PDB IDs		2DK6	5HOD
Enriched GO Terms of Interacting Partners?
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