AP1G2 and XRN1

Data Source:
HPRD (two hybrid)

		AP1G2	XRN1
Description		adaptor related protein complex 1 subunit gamma 2	5'-3' exoribonuclease 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Golgi-associated Vesicle Endosome Membrane Membrane AP-1 Adaptor Complex Transport Vesicle	P-body Nucleus Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Synapse
	Molecular Function	Protein Binding Clathrin Adaptor Activity Cargo Adaptor Activity	G-quadruplex RNA Binding RNA Binding 5'-3' Exoribonuclease Activity Protein Binding G-quadruplex DNA Binding Telomerase RNA Binding
	Biological Process	Intracellular Protein Transport Golgi To Vacuole Transport Receptor-mediated Endocytosis Viral Process Vesicle-mediated Transport	Nuclear-transcribed MRNA Catabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Regulation Of MRNA Stability Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Puromycin
Pathways		Lysosome Vesicle Biogenesis	mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Sudden cardiac arrest ( 21658281)	Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Waist-hip ratio ( 28552196)
Interacting Genes		13 interacting genes: AAGAB AFTPH AP1B1 AP1S1 AP1S2 ATXN1L CENPK KDM1A NEDD4 PRMT6 RABEP1 SYNRG XRN1	66 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1 CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MIR34C MIR429 MIR7-1 MTCH2 MTREX NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36
Entrez ID		8906	54464
HPRD ID		04638	10470
Ensembl ID		ENSG00000213983	ENSG00000114127
Uniprot IDs		O75843 Q86U03 Q86V28	Q8IZH2
PDB IDs		2E9G 2YMT 3ZHF 4BCX
Enriched GO Terms of Interacting Partners?
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