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XRN1 and PLEKHG2
Data Source:
BioGRID
(two hybrid)
XRN1
PLEKHG2
Description
5'-3' exoribonuclease 1
pleckstrin homology and RhoGEF domain containing G2
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
P-body
Nucleus
Cytosol
Plasma Membrane
Membrane
Dendrite
Neuronal Cell Body
Synapse
Cytosol
Molecular Function
G-quadruplex RNA Binding
RNA Binding
5'-3' Exoribonuclease Activity
Protein Binding
G-quadruplex DNA Binding
Telomerase RNA Binding
Protein Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process
RRNA Catabolic Process
Negative Regulation Of Translation
Negative Regulation Of Telomere Maintenance Via Telomerase
Response To Testosterone
Regulation Of MRNA Stability
Nuclear MRNA Surveillance
Histone MRNA Catabolic Process
Cellular Response To Cycloheximide
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Cellular Response To Puromycin
G Protein-coupled Receptor Signaling Pathway
Regulation Of Actin Filament Polymerization
Positive Regulation Of Apoptotic Process
Regulation Of Catalytic Activity
Regulation Of Small GTPase Mediated Signal Transduction
Pathways
mRNA decay by 5' to 3' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Benign childhood epilepsy with centro-temporal spikes (
32580138
)
Birth weight (
31043758
)
Heel bone mineral density (
30598549
)
Mean spheric corpuscular volume (
32888494
)
Mosquito bite size (
28199695
)
Waist-hip ratio (
28552196
)
Interacting Genes
66 interacting genes:
ADGRE5
ALDOA
ANGPTL6
AP1G2
ATP5MC2
B3GALT6
BAG6
C1GALT1
CBX5
CCT5
CENPBD1
CHD4
CTSB
CTSH
DCP1B
DNASE2
DPP7
DXO
EXOSC1
EXOSC10
EXOSC6
EXOSC8
FADS1
FBXO7
GLMP
HEATR1
HERC2P4
HNRNPA1
KATNB1
LDHA
LEPR
LGALS3BP
LINC01541
LSM4
MAN2C1
MFSD5
MIR34C
MIR429
MIR7-1
MTCH2
MTREX
NDUFA13
NDUFB10
NDUFB9
PABPC4
PLEKHG2
POLD2
PPP2CA
PRADC1
PSMB5
RBMX
RNF187
SDHB
SKIV2L
SMARCD2
SNHG1
SPATA20
SRRM2
STAM2
TMEM50A
UPF1
UPF2
UPF3B
VWA5B2
WAPL
ZFP36
8 interacting genes:
ACTN3
APP
CDC42
GNG2
PIN1
RAC1
RHOA
XRN1
Entrez ID
54464
64857
HPRD ID
10470
15148
Ensembl ID
ENSG00000114127
ENSG00000090924
Uniprot IDs
Q8IZH2
Q9H7P9
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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