XRN1 and PLEKHG2

Data Source:
BioGRID (two hybrid)

		XRN1	PLEKHG2
Description		5'-3' exoribonuclease 1	pleckstrin homology and RhoGEF domain containing G2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Synapse	Cytosol
	Molecular Function	G-quadruplex RNA Binding RNA Binding 5'-3' Exoribonuclease Activity Protein Binding G-quadruplex DNA Binding Telomerase RNA Binding	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Regulation Of MRNA Stability Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Puromycin	G Protein-coupled Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Waist-hip ratio ( 28552196)
Interacting Genes		66 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1 CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MIR34C MIR429 MIR7-1 MTCH2 MTREX NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36	8 interacting genes: ACTN3 APP CDC42 GNG2 PIN1 RAC1 RHOA XRN1
Entrez ID		54464	64857
HPRD ID		10470	15148
Ensembl ID		ENSG00000114127	ENSG00000090924
Uniprot IDs		Q8IZH2	Q9H7P9
PDB IDs
Enriched GO Terms of Interacting Partners?
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