XRN1 and MTCH2

Data Source:
BioGRID (two hybrid)

		XRN1	MTCH2
Description		5'-3' exoribonuclease 1	mitochondrial carrier 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Synapse	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Integral Component Of Membrane
	Molecular Function	G-quadruplex RNA Binding RNA Binding 5'-3' Exoribonuclease Activity Protein Binding G-quadruplex DNA Binding Telomerase RNA Binding	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Regulation Of MRNA Stability Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Puromycin	Positive Regulation Of Apoptotic Process Protein Localization To Mitochondrion
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Waist-hip ratio ( 28552196)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bitter beverage consumption ( 31046077) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 19079261 26961502 28892062 25673413 20935630 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Fruit consumption ( 32066663) General cognitive ability ( 29844566) Hypertension ( 31879980) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mood instability ( 31168069) Neuroticism ( 29255261) Pulse pressure ( 27841878) Refractive error ( 32231278) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 27841878)
Interacting Genes		66 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1 CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MIR34C MIR429 MIR7-1 MTCH2 MTREX NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36	5 interacting genes: APOC1 ATP5MJ ESR1 GLP1R XRN1
Entrez ID		54464	23788
HPRD ID		10470	14788
Ensembl ID		ENSG00000114127	ENSG00000109919
Uniprot IDs		Q8IZH2	B4DHQ0 Q9Y6C9
PDB IDs
Enriched GO Terms of Interacting Partners?
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