XRN1 and WAPL

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		XRN1	WAPL
Description		5'-3' exoribonuclease 1	WAPL cohesin release factor
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Synapse	Chromosome, Centromeric Region Chromatin Synaptonemal Complex Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Centrosome Cytosol Intercellular Bridge Mitotic Spindle
	Molecular Function	G-quadruplex RNA Binding RNA Binding 5'-3' Exoribonuclease Activity Protein Binding G-quadruplex DNA Binding Telomerase RNA Binding	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Regulation Of MRNA Stability Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Puromycin	Mitotic Cell Cycle Negative Regulation Of DNA Replication Response To Toxic Substance Viral Process Negative Regulation Of Chromatin Binding Negative Regulation Of Sister Chromatid Cohesion Positive Regulation Of Fibroblast Proliferation Cell Division Regulation Of Chromosome Segregation Regulation Of Chromosome Condensation Protein Localization To Chromatin Regulation Of Cohesin Loading
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion
Drugs
Diseases
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Waist-hip ratio ( 28552196)	Parental longevity (father's age at death) ( 31484785)
Interacting Genes		66 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1 CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MIR34C MIR429 MIR7-1 MTCH2 MTREX NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36	5 interacting genes: ARAP1 MTNR1A RAD21 SUMO2 XRN1
Entrez ID		54464	23063
HPRD ID		10470	11072
Ensembl ID		ENSG00000114127	ENSG00000062650
Uniprot IDs		Q8IZH2	A8K273 B2RTX8 Q7Z5K2
PDB IDs			4K6J 5HDT
Enriched GO Terms of Interacting Partners?
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