EIF2B4 and EIF2S1

Data Source:
HPRD (in vivo, in vitro)

		EIF2B4	EIF2S1
Description		eukaryotic translation initiation factor 2B subunit delta	eukaryotic translation initiation factor 2 subunit alpha
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding
	Biological Process	Ovarian Follicle Development Translational Initiation Regulation Of Translation Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway	Translational Initiation Aging Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Protein Autophosphorylation Transmembrane Transport Positive Regulation Of Neuron Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Recycling of eIF2:GDP	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Non-oily fish consumption ( 32066663)
Interacting Genes		3 interacting genes: EIF2B2 EIF2S1 EIF2S2	26 interacting genes: ACTN1 CASP3 CASP6 CDC37 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12 VAC14
Entrez ID		8890	1965
HPRD ID		09459	04881
Ensembl ID		ENSG00000115211	ENSG00000134001
Uniprot IDs		B4DUP5 E7ERK9 F8W8L6 Q71US4 Q9HBP7 Q9UI10	P05198 Q53XC0
PDB IDs		6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z	1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z 6YBV 6ZMW 6ZP4 7A09
Enriched GO Terms of Interacting Partners?
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