EIF2S1 and EIF2AK1

Data Source:
HPRD (in vivo)

		EIF2S1	EIF2AK1
Description		eukaryotic translation initiation factor 2 subunit alpha	eukaryotic translation initiation factor 2 alpha kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot	Cytoplasm
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding	Protein Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Heme Binding Protein Homodimerization Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Translational Initiation Aging Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Protein Autophosphorylation Transmembrane Transport Positive Regulation Of Neuron Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Acute Inflammatory Response Phagocytosis Negative Regulation Of Cell Population Proliferation Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of EIF2 Alpha Phosphorylation By Heme Macrophage Differentiation Negative Regulation Of Translational Initiation By Iron Protoporphyrinogen IX Metabolic Process Protein Autophosphorylation Negative Regulation Of Hemoglobin Biosynthetic Process Iron Ion Homeostasis Integrated Stress Response Signaling HRI-mediated Signaling Response To Iron Ion Starvation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Response of EIF2AK1 (HRI) to heme deficiency
Drugs			Fostamatinib
Diseases
GWAS			High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		26 interacting genes: ACTN1 CASP3 CASP6 CDC37 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12 VAC14	4 interacting genes: CDC37 EIF2S1 HSP90AA1 LIG4
Entrez ID		1965	27102
HPRD ID		04881	10684
Ensembl ID		ENSG00000134001	ENSG00000086232
Uniprot IDs		P05198 Q53XC0	A0A024QZU1 Q9BQI3
PDB IDs		1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z 6YBV 6ZMW 6ZP4 7A09
Enriched GO Terms of Interacting Partners?
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