EIF2S1 and PPP1R15A

Data Source:
HPRD (in vitro, in vivo)

		EIF2S1	PPP1R15A
Description		eukaryotic translation initiation factor 2 subunit alpha	protein phosphatase 1 regulatory subunit 15A
Image
GO Annotations	Cellular Component	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Protein Kinase Binding Protein Phosphatase Activator Activity
	Biological Process	Translational Initiation Aging Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Protein Autophosphorylation Transmembrane Transport Positive Regulation Of Neuron Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Positive Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Dephosphorylation Regulation Of Translational Initiation By EIF2 Alpha Dephosphorylation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Positive Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Dephosphorylation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS			High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		26 interacting genes: ACTN1 CASP3 CASP6 CDC37 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12 VAC14	16 interacting genes: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B
Entrez ID		1965	23645
HPRD ID		04881	06572
Ensembl ID		ENSG00000134001	ENSG00000087074
Uniprot IDs		P05198 Q53XC0	O75807
PDB IDs		1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z 6YBV 6ZMW 6ZP4 7A09	4XPN
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?