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EIF2S1 and MELK
Data Source:
HPRD
(in vivo)
EIF2S1
MELK
Description
eukaryotic translation initiation factor 2 subunit alpha
maternal embryonic leucine zipper kinase
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Polysome
Eukaryotic Translation Initiation Factor 2 Complex
Eukaryotic Translation Initiation Factor 2B Complex
Cytoplasmic Stress Granule
Membrane
Eukaryotic 48S Preinitiation Complex
Multi-eIF Complex
Translation Initiation Ternary Complex
Synapse
Extracellular Exosome
Glial Limiting End-foot
Nucleus
Cytoplasm
Plasma Membrane
Cell Cortex
Membrane
Molecular Function
RNA Binding
Translation Initiation Factor Activity
Protein Binding
Ribosome Binding
Protein Serine/threonine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Lipid Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Translational Initiation
Aging
Negative Regulation Of Translational Initiation In Response To Stress
Stress Granule Assembly
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To UV
Response To Endoplasmic Reticulum Stress
PERK-mediated Unfolded Protein Response
Protein Autophosphorylation
Transmembrane Transport
Positive Regulation Of Neuron Death
Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Response To Manganese-induced Endoplasmic Reticulum Stress
Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
G2/M Transition Of Mitotic Cell Cycle
Protein Phosphorylation
Apoptotic Process
Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Protein Autophosphorylation
Neural Precursor Cell Proliferation
Pathways
L13a-mediated translational silencing of Ceruloplasmin expression
PERK regulates gene expression
PERK regulates gene expression
ABC-family proteins mediated transport
Translation initiation complex formation
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Recycling of eIF2:GDP
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Fostamatinib
Diseases
GWAS
Interacting Genes
26 interacting genes:
ACTN1
CASP3
CASP6
CDC37
CSNK2A1
EIF1AX
EIF2AK1
EIF2AK2
EIF2AK3
EIF2B1
EIF2B2
EIF2B3
EIF2B4
EIF2S2
HSP90AA1
HSPB1
MELK
P4HB
PPP1R15A
PRKCA
PRKCD
PRMT7
SFN
TERT
THAP12
VAC14
11 interacting genes:
CDC25B
CDC5L
EIF2S1
EZH2
H1-5
LMNB1
MAPT
MBP
PPP1R8
SF3B1
ZNF622
Entrez ID
1965
9833
HPRD ID
04881
06119
Ensembl ID
ENSG00000134001
ENSG00000165304
Uniprot IDs
P05198
Q53XC0
B7Z1G6
Q14680
PDB IDs
1KL9
1Q8K
6K71
6K72
6O81
6O85
6O9Z
6YBV
6ZMW
6ZP4
7A09
4BKY
4BKZ
4BL1
4D2P
4D2T
4D2V
4D2W
4IXP
4UMP
4UMQ
4UMR
4UMT
4UMU
5IH8
5IH9
5IHA
5IHC
5K00
5M5A
5MAF
5MAG
5MAH
5MAI
5TVT
5TWL
5TWU
5TWY
5TWZ
5TX3
6GVX
6VXR
Enriched GO Terms of Interacting Partners
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