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EIF2S1 and VAC14
Data Source:
BioGRID
(two hybrid)
EIF2S1
VAC14
Description
eukaryotic translation initiation factor 2 subunit alpha
VAC14 component of PIKFYVE complex
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytosol
Polysome
Eukaryotic Translation Initiation Factor 2 Complex
Eukaryotic Translation Initiation Factor 2B Complex
Cytoplasmic Stress Granule
Membrane
Eukaryotic 48S Preinitiation Complex
Multi-eIF Complex
Translation Initiation Ternary Complex
Synapse
Extracellular Exosome
Glial Limiting End-foot
Golgi Membrane
Extrinsic Component Of Vacuolar Membrane
Endoplasmic Reticulum
Cytosol
Endosome Membrane
Early Endosome Membrane
Late Endosome Membrane
Intracellular Membrane-bounded Organelle
PAS Complex
Molecular Function
RNA Binding
Translation Initiation Factor Activity
Protein Binding
Ribosome Binding
Protein Binding
Signaling Receptor Activity
Identical Protein Binding
Biological Process
Translational Initiation
Aging
Negative Regulation Of Translational Initiation In Response To Stress
Stress Granule Assembly
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To UV
Response To Endoplasmic Reticulum Stress
PERK-mediated Unfolded Protein Response
Protein Autophosphorylation
Transmembrane Transport
Positive Regulation Of Neuron Death
Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Response To Manganese-induced Endoplasmic Reticulum Stress
Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Phosphatidylinositol Biosynthetic Process
Signal Transduction
Viral Process
Positive Regulation Of Kinase Activity
Pathways
L13a-mediated translational silencing of Ceruloplasmin expression
PERK regulates gene expression
PERK regulates gene expression
ABC-family proteins mediated transport
Translation initiation complex formation
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Recycling of eIF2:GDP
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane
Synthesis of PIPs at the late endosome membrane
Drugs
Diseases
GWAS
Diffuse cutaneous systemic sclerosis (
29293537
)
Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer (
27143689
)
High density lipoprotein cholesterol levels (
28548082
)
Hippocampal volume in Alzheimer's disease dementia (
29274321
)
Malaria (
31844061
)
Pulse pressure (
28135244
)
Interacting Genes
26 interacting genes:
ACTN1
CASP3
CASP6
CDC37
CSNK2A1
EIF1AX
EIF2AK1
EIF2AK2
EIF2AK3
EIF2B1
EIF2B2
EIF2B3
EIF2B4
EIF2S2
HSP90AA1
HSPB1
MELK
P4HB
PPP1R15A
PRKCA
PRKCD
PRMT7
SFN
TERT
THAP12
VAC14
107 interacting genes:
ABHD11
ACSS1
AMT
APP
ARID5A
ASB13
BCL2L1
BHLHE40
C11orf54
C19orf54
C2CD6
C4orf33
CASP1
CCDC103
CD209
CDRT4
CNTN2
COL8A1
CRK
CRYBA1
CRYBA2
DDAH2
EEF1AKMT3
EHHADH
EIF2S1
EIF6
FAM50B
FIG4
FNDC3B
GABPB2
GALT
GINS3
GLIS2
GNB1
GTF3C2
HDHD3
HNF1B
HNRNPLL
INTS11
JMJD7
KHDC1
KRT82
KRTAP15-1
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP6-1
KRTAP6-2
KYAT1
LASP1
LINC00518
LPAL2
MBLAC1
MEOX2
METTL15
MGAT5B
MPPED2
MTMR9
MVP
MYOZ1
NDUFAB1
NGB
NOS1
NTAQ1
OIT3
OTOS
PBLD
PCMTD2
PDE4DIP
PELI1
PHF1
PHYKPL
PIKFYVE
PPP2CA
PPP6C
PRADC1
PRR13
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
RBFOX2
RHBDL1
RHOXF2
RIPPLY1
RNASEH2C
RSKR
SIGLEC5
SMUG1
SNF8
SPRYD7
SRPK2
TCEANC
TEX37
TP53BP1
TRIM55
TRIM63
UFSP1
VENTX
VHLL
WDR83
WRAP53
ZBTB49
ZCWPW1
ZNF34
ZNF720
Entrez ID
1965
55697
HPRD ID
04881
07660
Ensembl ID
ENSG00000134001
ENSG00000103043
Uniprot IDs
P05198
Q53XC0
Q08AM6
PDB IDs
1KL9
1Q8K
6K71
6K72
6O81
6O85
6O9Z
6YBV
6ZMW
6ZP4
7A09
Enriched GO Terms of Interacting Partners
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