EIF2S1 and THAP12

Data Source:
HPRD (in vivo, in vitro)

		EIF2S1	THAP12
Description		eukaryotic translation initiation factor 2 subunit alpha	THAP domain containing 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot	Nucleus
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding	DNA Binding Protein Binding Metal Ion Binding Protein Dimerization Activity
	Biological Process	Translational Initiation Aging Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Protein Autophosphorylation Transmembrane Transport Positive Regulation Of Neuron Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Signal Transduction Negative Regulation Of Cell Population Proliferation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS			Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433)
Interacting Genes		26 interacting genes: ACTN1 CASP3 CASP6 CDC37 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12 VAC14	10 interacting genes: DDX58 DNAJC3 EIF2AK2 EIF2S1 KIAA1958 MAPKAPK3 STK4 TACC1 TP53 ZNF526
Entrez ID		1965	5612
HPRD ID		04881	09567
Ensembl ID		ENSG00000134001	ENSG00000137492
Uniprot IDs		P05198 Q53XC0	A0A140VJQ7 O43422
PDB IDs		1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z 6YBV 6ZMW 6ZP4 7A09
Enriched GO Terms of Interacting Partners?
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