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KAT2B and POLR2A
Data Source:
BioGRID
(affinity chromatography technology, pull down)
KAT2B
POLR2A
Description
lysine acetyltransferase 2B
RNA polymerase II subunit A
Image
GO Annotations
Cellular Component
PCAF Complex
Kinetochore
Nucleus
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
Centrosome
Cytosol
A Band
I Band
Protein-containing Complex
Actomyosin
Prp19 Complex
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Chromosome
Nucleolus
Cytoplasm
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Diamine N-acetyltransferase Activity
Histone Acetyltransferase Activity
Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Transcription Factor Binding
Acetyltransferase Activity
Protein Kinase Binding
Histone Deacetylase Binding
Peptide-lysine-N-acetyltransferase Activity
RNA Polymerase II Activity
DNA Binding
RNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
RNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Protein C-terminus Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Promoter-specific Chromatin Binding
Biological Process
Chromatin Remodeling
Transcription Initiation From RNA Polymerase II Promoter
Protein Acetylation
Cell Cycle Arrest
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Heart Development
Negative Regulation Of Cell Population Proliferation
Regulation Of Protein ADP-ribosylation
Viral Process
Protein Deubiquitination
N-terminal Peptidyl-lysine Acetylation
Protein Phosphopantetheinylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Cellular Response To Insulin Stimulus
Histone H3 Acetylation
Histone H3-K9 Acetylation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Rhythmic Process
Limb Development
Negative Regulation Of RRNA Processing
MRNA Splicing, Via Spliceosome
Transcription, RNA-templated
Transcription-coupled Nucleotide-excision Repair
Transcription, DNA-templated
DNA-templated Transcription, Termination
Regulation Of Transcription, DNA-templated
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Fibroblast Growth Factor Receptor Signaling Pathway
Viral Process
RNA Metabolic Process
Positive Regulation Of RNA Splicing
Somatic Stem Cell Population Maintenance
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Viral Transcription
Regulation Of Gene Silencing By MiRNA
Pathways
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HATs acetylate histones
Notch-HLH transcription pathway
B-WICH complex positively regulates rRNA expression
Physiological factors
Metalloprotease DUBs
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Estrogen-dependent gene expression
Regulation of FOXO transcriptional activity by acetylation
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
Drugs
Coenzyme A
(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Diseases
GWAS
Drug abuse (
26202629
)
High light scatter reticulocyte count (
32888494
)
Mean arterial pressure (alcohol consumption interaction) (
24376456
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
29403010
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Optic disc size (
31809533
)
Post-traumatic stress disorder (
24677629
)
Red blood cell count (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Staphylococcus aureus nasal carriage (intermittent) (
26569114
)
Systolic blood pressure (
30224653
30578418
)
Atrial fibrillation (
29892015
)
Brain morphology (MOSTest) (
32665545
)
Central corneal thickness (
29760442
)
Heel bone mineral density (
30598549
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean platelet volume (
32888494
)
Myopia (
27182965
)
Refractive error (
32231278
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Interacting Genes
121 interacting genes:
ACTN1
ACTN2
AKT1
AR
ARHGDIA
ARNTL
ATF4
ATXN3
BRCA2
CCNA2
CCND1
CCNT1
CDC25B
CDCA4
CDK2
CDKN1B
CDT1
CEBPB
CEP250
CIITA
CLOCK
CREBBP
CTBP1
CTNNB1
CUX1
DACH2
DEK
EP300
ESRRA
ETV1
EZH2
GATAD2A
GATAD2B
H1-1
H1-5
H2AC20
H2AC4
H2BC21
H2BC3
H3-3A
H3-4
H3C1
H3C14
H4-16
H4C1
HIPK2
HMGA1
HMGN2
HNF1A
HNRNPU
HOXB9
HSD11B2
HTT
ING1
IRF1
IRF2
IRF7
JDP2
KLF10
KLF13
KLF2
LIN28B
MAPK14
MAPRE1
MDM2
MECOM
MYC
MYOD1
NCOA1
NCOA3
NCOA4
NFATC1
NFE2
NFE4
NOTCH1
NOTCH3
NPAS2
NR1H3
NR4A1
NRIP1
ONECUT1
PARP1
PDK1
PGR
PLAGL1
PNMA1
POLR2A
PTF1A
RAB11A
RARA
RB1
RBM8A
RBPJ
RELA
RPS6KB1
RPS6KB2
SAT2
SATB1
SERBP1
SERTAD1
SERTAD2
SIRT2
SMAD1
SMAD2
SMAD3
SRCAP
TACC2
TAL1
TCF3
TMF1
TP53
TP63
TP73
TRIM14
TTF1
TWIST1
UBE2D1
UBE2D2
UBE2D3
XRCC6
YY1
108 interacting genes:
ABL1
ACTB
ACTL6A
ASB6
ATM
BARD1
BRCA1
CALCOCO1
CALCOCO2
CASP10
CCNH
CCNK
CCNL2
CCNT1
CDC14A
CDK12
CDK7
CDK8
CDK9
CPSF1
CPSF2
CPSF3
CREBBP
CSH2
CSNK2A1
CSTF1
CSTF2
CTCF
CTDP1
CTDSP1
CTDSP2
DHX9
ELL
ELOA
ERCC5
ERCC6
ERG
ESR1
FUS
GRB2
GTF2B
GTF2E1
GTF2F1
GTF2H1
GTF2H4
H1-2
HNRNPF
HNRNPU
HTATSF1
IFTAP
ITCH
IWS1
KAT2B
KLK2
KMT2D
LEO1
MCM3
MED21
MNAT1
MYH6
NEDD4
NONO
NR0B2
NSD1
OTUD5
PCIF1
PHF8
PIN1
POLR2C
POLR2D
POLR2E
POLR2F
POLR2G
POLR2H
POLR2I
POLR2L
PPIG
PPP1CA
PQBP1
PRMT5
PRPF19
PTEN
SAFB
SKP2
SMN1
SMN2
SMURF1
SNAR-B2
SND1
SUB1
SUMO2
SUPT5H
TAF10
TBP
TCEA1
TCERG1
TDRD3
TRAK1
TRAM2
TTK
U2AF2
UBE2L3
UPF1
VDR
WAC
XAB2
XRCC5
ZNF74
Entrez ID
8850
5430
HPRD ID
06780
08916
Ensembl ID
ENSG00000114166
ENSG00000181222
Uniprot IDs
Q92831
P24928
PDB IDs
1CM0
1JM4
1N72
1WUG
1WUM
1ZS5
2RNW
2RNX
3GG3
4NSQ
5FDZ
5FE0
5FE1
5FE2
5FE3
5FE4
5FE5
5FE6
5FE7
5FE8
5FE9
5LVQ
5LVR
5MKX
6J3O
2GHQ
2GHT
2LTO
3D9K
3D9L
3D9M
3D9N
3D9O
3D9P
4JXT
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
5M3H
5M3J
6DRD
6F5P
6G0R
6IC8
6IC9
6O9L
6Q5Y
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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