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KAT2B and YY1
Data Source:
BioGRID
(enzymatic study)
KAT2B
YY1
Description
lysine acetyltransferase 2B
YY1 transcription factor
Image
GO Annotations
Cellular Component
PCAF Complex
Kinetochore
Nucleus
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
Centrosome
Cytosol
A Band
I Band
Protein-containing Complex
Actomyosin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromatin Silencing Complex
Cytoplasm
Nuclear Matrix
Ino80 Complex
PcG Protein Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Diamine N-acetyltransferase Activity
Histone Acetyltransferase Activity
Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Transcription Factor Binding
Acetyltransferase Activity
Protein Kinase Binding
Histone Deacetylase Binding
Peptide-lysine-N-acetyltransferase Activity
Four-way Junction DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
RNA Binding
Protein Binding
SMAD Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Chromatin Remodeling
Transcription Initiation From RNA Polymerase II Promoter
Protein Acetylation
Cell Cycle Arrest
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Heart Development
Negative Regulation Of Cell Population Proliferation
Regulation Of Protein ADP-ribosylation
Viral Process
Protein Deubiquitination
N-terminal Peptidyl-lysine Acetylation
Protein Phosphopantetheinylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Cellular Response To Insulin Stimulus
Histone H3 Acetylation
Histone H3-K9 Acetylation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Rhythmic Process
Limb Development
Negative Regulation Of RRNA Processing
Negative Regulation Of Transcription By RNA Polymerase II
Double-strand Break Repair Via Homologous Recombination
Regulation Of Transcription By RNA Polymerase II
RNA Localization
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Anterior/posterior Pattern Specification
Response To UV-C
Negative Regulation Of Gene Expression
Protein Deubiquitination
B Cell Differentiation
Negative Regulation Of Interferon-beta Production
Cellular Response To UV
Response To Prostaglandin F
Positive Regulation Of Transcription By RNA Polymerase II
Cell Development
Camera-type Eye Morphogenesis
Chromosome Organization
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Interleukin-1
Immunoglobulin Heavy Chain V-D-J Recombination
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HATs acetylate histones
Notch-HLH transcription pathway
B-WICH complex positively regulates rRNA expression
Physiological factors
Metalloprotease DUBs
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Estrogen-dependent gene expression
Regulation of FOXO transcriptional activity by acetylation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
UCH proteinases
DNA Damage Recognition in GG-NER
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Estrogen-dependent gene expression
Drugs
Coenzyme A
(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Diseases
GWAS
Drug abuse (
26202629
)
High light scatter reticulocyte count (
32888494
)
Mean arterial pressure (alcohol consumption interaction) (
24376456
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
29403010
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Optic disc size (
31809533
)
Post-traumatic stress disorder (
24677629
)
Red blood cell count (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Staphylococcus aureus nasal carriage (intermittent) (
26569114
)
Systolic blood pressure (
30224653
30578418
)
Estimated glomerular filtration rate (
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Pulse pressure (
30224653
)
Interacting Genes
121 interacting genes:
ACTN1
ACTN2
AKT1
AR
ARHGDIA
ARNTL
ATF4
ATXN3
BRCA2
CCNA2
CCND1
CCNT1
CDC25B
CDCA4
CDK2
CDKN1B
CDT1
CEBPB
CEP250
CIITA
CLOCK
CREBBP
CTBP1
CTNNB1
CUX1
DACH2
DEK
EP300
ESRRA
ETV1
EZH2
GATAD2A
GATAD2B
H1-1
H1-5
H2AC20
H2AC4
H2BC21
H2BC3
H3-3A
H3-4
H3C1
H3C14
H4-16
H4C1
HIPK2
HMGA1
HMGN2
HNF1A
HNRNPU
HOXB9
HSD11B2
HTT
ING1
IRF1
IRF2
IRF7
JDP2
KLF10
KLF13
KLF2
LIN28B
MAPK14
MAPRE1
MDM2
MECOM
MYC
MYOD1
NCOA1
NCOA3
NCOA4
NFATC1
NFE2
NFE4
NOTCH1
NOTCH3
NPAS2
NR1H3
NR4A1
NRIP1
ONECUT1
PARP1
PDK1
PGR
PLAGL1
PNMA1
POLR2A
PTF1A
RAB11A
RARA
RB1
RBM8A
RBPJ
RELA
RPS6KB1
RPS6KB2
SAT2
SATB1
SERBP1
SERTAD1
SERTAD2
SIRT2
SMAD1
SMAD2
SMAD3
SRCAP
TACC2
TAL1
TCF3
TMF1
TP53
TP63
TP73
TRIM14
TTF1
TWIST1
UBE2D1
UBE2D2
UBE2D3
XRCC6
YY1
90 interacting genes:
ALOXE3
APP
ATF2
ATF6
ATF7
AURKA
BAP1
BCCIP
BRCA1
CDKN2A
CEP76
CREB1
CRKL
CYSRT1
DNMT3L
E2F2
E2F3
EED
EP300
ESM1
FHL2
FKBP1A
FKBP3
GMCL1
GRN
GTF2I
HCFC1
HDAC2
HDAC3
HOXA11
IL10
INO80
KAT2B
KRTAP1-3
KRTAP1-5
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP12-3
KRTAP17-1
KRTAP2-3
KRTAP2-4
KRTAP4-2
KRTAP4-5
KRTAP5-6
KRTAP9-3
KRTAP9-8
LHX3
LHX4
MDFI
MED20
MTA2
MYC
NEDD4L
NFKB1
NOTCH1
NPM1
NR1H2
PLEKHF2
PPIA
PSMD9
RAF1
RUVBL1
RUVBL2
RYBP
SAP30
SF3A2
SKP2
SLC39A7
SMAD1
SMAD2
SMAD3
SMURF2
SP1
SPRY1
SREBF1
TESK1
TFCP2
TP53
TRIM42
TWIST1
UHRF2
VWC2
XAGE1A
XAGE1B
YAF2
ZNF232
ZNF85
ZRANB2
Entrez ID
8850
7528
HPRD ID
06780
02482
Ensembl ID
ENSG00000114166
ENSG00000100811
Uniprot IDs
Q92831
P25490
PDB IDs
1CM0
1JM4
1N72
1WUG
1WUM
1ZS5
2RNW
2RNX
3GG3
4NSQ
5FDZ
5FE0
5FE1
5FE2
5FE3
5FE4
5FE5
5FE6
5FE7
5FE8
5FE9
5LVQ
5LVR
5MKX
6J3O
1UBD
1ZNM
4C5I
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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