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POLR2A and CALCOCO2
Data Source:
BioGRID
(pull down)
POLR2A
CALCOCO2
Description
RNA polymerase II subunit A
calcium binding and coiled-coil domain 2
Image
GO Annotations
Cellular Component
Prp19 Complex
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Chromosome
Nucleolus
Cytoplasm
Autophagosome Membrane
Nucleus
Cytoplasm
Autophagosome
Cytosol
Cytoskeleton
Membrane
PML Body
Cytoplasmic Vesicle
Intracellular Membrane-bounded Organelle
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Polymerase II Activity
DNA Binding
RNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
RNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Protein C-terminus Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Promoter-specific Chromatin Binding
Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Biological Process
MRNA Splicing, Via Spliceosome
Transcription, RNA-templated
Transcription-coupled Nucleotide-excision Repair
Transcription, DNA-templated
DNA-templated Transcription, Termination
Regulation Of Transcription, DNA-templated
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Fibroblast Growth Factor Receptor Signaling Pathway
Viral Process
RNA Metabolic Process
Positive Regulation Of RNA Splicing
Somatic Stem Cell Population Maintenance
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Viral Transcription
Regulation Of Gene Silencing By MiRNA
Viral Process
Response To Interferon-gamma
Xenophagy
Positive Regulation Of Autophagosome Maturation
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Atrial fibrillation (
29892015
)
Brain morphology (MOSTest) (
32665545
)
Central corneal thickness (
29760442
)
Heel bone mineral density (
30598549
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean platelet volume (
32888494
)
Myopia (
27182965
)
Refractive error (
32231278
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Blood protein levels (
30072576
)
Chronotype (
30696823
)
Type 2 diabetes (
29358691
29632382
)
Type 2 diabetes (adjusted for BMI) (
29632382
)
Interacting Genes
108 interacting genes:
ABL1
ACTB
ACTL6A
ASB6
ATM
BARD1
BRCA1
CALCOCO1
CALCOCO2
CASP10
CCNH
CCNK
CCNL2
CCNT1
CDC14A
CDK12
CDK7
CDK8
CDK9
CPSF1
CPSF2
CPSF3
CREBBP
CSH2
CSNK2A1
CSTF1
CSTF2
CTCF
CTDP1
CTDSP1
CTDSP2
DHX9
ELL
ELOA
ERCC5
ERCC6
ERG
ESR1
FUS
GRB2
GTF2B
GTF2E1
GTF2F1
GTF2H1
GTF2H4
H1-2
HNRNPF
HNRNPU
HTATSF1
IFTAP
ITCH
IWS1
KAT2B
KLK2
KMT2D
LEO1
MCM3
MED21
MNAT1
MYH6
NEDD4
NONO
NR0B2
NSD1
OTUD5
PCIF1
PHF8
PIN1
POLR2C
POLR2D
POLR2E
POLR2F
POLR2G
POLR2H
POLR2I
POLR2L
PPIG
PPP1CA
PQBP1
PRMT5
PRPF19
PTEN
SAFB
SKP2
SMN1
SMN2
SMURF1
SNAR-B2
SND1
SUB1
SUMO2
SUPT5H
TAF10
TBP
TCEA1
TCERG1
TDRD3
TRAK1
TRAM2
TTK
U2AF2
UBE2L3
UPF1
VDR
WAC
XAB2
XRCC5
ZNF74
180 interacting genes:
ABLIM1
ADSL
AKAP17A
AMMECR1
AP5B1
APEX2
ARHGEF39
ARHGEF5
ARNT2
ATG5
AXIN1
BAHD1
BCL6B
BEX2
CBX8
CCDC120
CCDC185
CCDC33
CCNH
CDC7
CELA2B
CEP57L1
CHCHD3
CNNM3
CPNE7
CWF19L2
DAXX
DAZAP2
DBNDD2
DCTN4
DCX
DDIT4L
DDX6
DOCK2
DUSP12
DUSP26
EEF1E1
EFHC1
ELOA2
ENKD1
EXOSC5
FAM107A
FAM161A
FAM168A
FAM189A2
FAM214B
FAM90A1
FARS2
FASTK
FBF1
FBXL18
FKBPL
FNDC11
FOXD4L3
FXR2
GABARAPL1
GABARAPL2
GATAD2B
GCA
GEMIN4
GIT2
GLYCTK
HDAC4
HDAC7
HLX
HNRNPLL
HOXB5
HOXB9
IKBKG
IL16
IQUB
KANSL1
KAT7
KLHL35
KLHL42
LENG1
LGALS8
LIMS2
LITAF
LMF2
LMO2
LMO4
LNX1
LONRF1
LSM4
MAGOHB
MAP1LC3C
MCM10
METTL17
MID2
MOS
MTPAP
MVP
MXI1
MYH6
MYO6
NAA10
NDN
NFU1
ORC5
PCGF1
PEF1
PEG10
PFDN5
PHF1
PIAS4
PLEKHN1
POLI
POLR2A
PPP1R18
PRKAA2
PRKAB2
PRPF18
PRPF31
PSMA1
PSME4
PTBP1
PTBP2
QARS1
RAB35
RABL6
RBM15
RHPN1
RIN1
RNF11
RPA2
RPL9
RPS27A
RTN4IP1
RTP5
RXRB
SCAND1
SCNM1
SDCBP
SETD5
SHC1
SLC15A3
SMARCD1
SMCP
SNRPB
SPATA24
SRI
STAMBPL1
STK16
TACO1
TBC1D22B
TBK1
TBKBP1
TBRG4
TCL1A
TEKT3
TENT2
TLE5
TP53RK
TRAF2
TRAF4
TRAF6
TSGA10IP
TTC23L
UBAC2
USP2
VARS1
VPS72
ZBTB4
ZC2HC1C
ZNF101
ZNF205
ZNF337
ZNF408
ZNF414
ZNF426
ZNF451
ZNF564
ZNF581
ZNF638
ZNF648
ZNF688
ZNF696
ZNF774
ZNF80
Entrez ID
5430
10241
HPRD ID
08916
06846
Ensembl ID
ENSG00000181222
ENSG00000136436
Uniprot IDs
P24928
Q13137
PDB IDs
2GHQ
2GHT
2LTO
3D9K
3D9L
3D9M
3D9N
3D9O
3D9P
4JXT
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
5M3H
5M3J
6DRD
6F5P
6G0R
6IC8
6IC9
6O9L
6Q5Y
2MXP
3VVV
3VVW
4GXL
4HAN
4XKL
5AAQ
5Z7A
5Z7L
Enriched GO Terms of Interacting Partners
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