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POLR2A and CPSF3
Data Source:
BioGRID
(pull down, biochemical)
HPRD
(in vitro)
POLR2A
CPSF3
Description
RNA polymerase II subunit A
cleavage and polyadenylation specific factor 3
Image
GO Annotations
Cellular Component
Prp19 Complex
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Chromosome
Nucleolus
Cytoplasm
Nucleoplasm
MRNA Cleavage And Polyadenylation Specificity Factor Complex
Molecular Function
RNA Polymerase II Activity
DNA Binding
RNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
RNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Protein C-terminus Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Promoter-specific Chromatin Binding
RNA Binding
Endoribonuclease Activity
Protein Binding
5'-3' Exonuclease Activity
Metal Ion Binding
Biological Process
MRNA Splicing, Via Spliceosome
Transcription, RNA-templated
Transcription-coupled Nucleotide-excision Repair
Transcription, DNA-templated
DNA-templated Transcription, Termination
Regulation Of Transcription, DNA-templated
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Fibroblast Growth Factor Receptor Signaling Pathway
Viral Process
RNA Metabolic Process
Positive Regulation Of RNA Splicing
Somatic Stem Cell Population Maintenance
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Viral Transcription
Regulation Of Gene Silencing By MiRNA
MRNA Splicing, Via Spliceosome
Termination Of RNA Polymerase II Transcription
MRNA Polyadenylation
MRNA Cleavage
MRNA 3'-end Processing By Stem-loop Binding And Cleavage
MRNA Export From Nucleus
MRNA 3'-end Processing
RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
Transport of Mature mRNA Derived from an Intronless Transcript
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS
Atrial fibrillation (
29892015
)
Brain morphology (MOSTest) (
32665545
)
Central corneal thickness (
29760442
)
Heel bone mineral density (
30598549
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean platelet volume (
32888494
)
Myopia (
27182965
)
Refractive error (
32231278
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Interacting Genes
108 interacting genes:
ABL1
ACTB
ACTL6A
ASB6
ATM
BARD1
BRCA1
CALCOCO1
CALCOCO2
CASP10
CCNH
CCNK
CCNL2
CCNT1
CDC14A
CDK12
CDK7
CDK8
CDK9
CPSF1
CPSF2
CPSF3
CREBBP
CSH2
CSNK2A1
CSTF1
CSTF2
CTCF
CTDP1
CTDSP1
CTDSP2
DHX9
ELL
ELOA
ERCC5
ERCC6
ERG
ESR1
FUS
GRB2
GTF2B
GTF2E1
GTF2F1
GTF2H1
GTF2H4
H1-2
HNRNPF
HNRNPU
HTATSF1
IFTAP
ITCH
IWS1
KAT2B
KLK2
KMT2D
LEO1
MCM3
MED21
MNAT1
MYH6
NEDD4
NONO
NR0B2
NSD1
OTUD5
PCIF1
PHF8
PIN1
POLR2C
POLR2D
POLR2E
POLR2F
POLR2G
POLR2H
POLR2I
POLR2L
PPIG
PPP1CA
PQBP1
PRMT5
PRPF19
PTEN
SAFB
SKP2
SMN1
SMN2
SMURF1
SNAR-B2
SND1
SUB1
SUMO2
SUPT5H
TAF10
TBP
TCEA1
TCERG1
TDRD3
TRAK1
TRAM2
TTK
U2AF2
UBE2L3
UPF1
VDR
WAC
XAB2
XRCC5
ZNF74
9 interacting genes:
CLP1
FAM107A
HSPB1
MIR19A
MIR19B1
MIR92A2
PAPOLA
POLR2A
YWHAG
Entrez ID
5430
51692
HPRD ID
08916
05825
Ensembl ID
ENSG00000181222
ENSG00000119203
Uniprot IDs
P24928
G5E9W3
Q9UKF6
PDB IDs
2GHQ
2GHT
2LTO
3D9K
3D9L
3D9M
3D9N
3D9O
3D9P
4JXT
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
5M3H
5M3J
6DRD
6F5P
6G0R
6IC8
6IC9
6O9L
6Q5Y
2I7T
2I7V
6M8Q
6V4X
Enriched GO Terms of Interacting Partners
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