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KAT2B and H4-16
Data Source:
BioGRID
(enzymatic study, enzymatic study)
KAT2B
H4-16
Description
lysine acetyltransferase 2B
H4 histone 16
Image
GO Annotations
Cellular Component
PCAF Complex
Kinetochore
Nucleus
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
Centrosome
Cytosol
A Band
I Band
Protein-containing Complex
Actomyosin
Nuclear Chromosome
Chromosome, Telomeric Region
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein-containing Complex
Extracellular Exosome
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Diamine N-acetyltransferase Activity
Histone Acetyltransferase Activity
Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Transcription Factor Binding
Acetyltransferase Activity
Protein Kinase Binding
Histone Deacetylase Binding
Peptide-lysine-N-acetyltransferase Activity
DNA Binding
RNA Binding
Protein Binding
Protein Domain Specific Binding
Protein Heterodimerization Activity
Biological Process
Chromatin Remodeling
Transcription Initiation From RNA Polymerase II Promoter
Protein Acetylation
Cell Cycle Arrest
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Heart Development
Negative Regulation Of Cell Population Proliferation
Regulation Of Protein ADP-ribosylation
Viral Process
Protein Deubiquitination
N-terminal Peptidyl-lysine Acetylation
Protein Phosphopantetheinylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Cellular Response To Insulin Stimulus
Histone H3 Acetylation
Histone H3-K9 Acetylation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Rhythmic Process
Limb Development
Negative Regulation Of RRNA Processing
RDNA Heterochromatin Assembly
Double-strand Break Repair Via Nonhomologous End Joining
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
DNA-templated Transcription, Initiation
Telomere Capping
Telomere Organization
CENP-A Containing Nucleosome Assembly
Cellular Protein Metabolic Process
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Gene Silencing By MiRNA
Pathways
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HATs acetylate histones
Notch-HLH transcription pathway
B-WICH complex positively regulates rRNA expression
Physiological factors
Metalloprotease DUBs
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Estrogen-dependent gene expression
Regulation of FOXO transcriptional activity by acetylation
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Coenzyme A
(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Diseases
GWAS
Drug abuse (
26202629
)
High light scatter reticulocyte count (
32888494
)
Mean arterial pressure (alcohol consumption interaction) (
24376456
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
29403010
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Optic disc size (
31809533
)
Post-traumatic stress disorder (
24677629
)
Red blood cell count (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Staphylococcus aureus nasal carriage (intermittent) (
26569114
)
Systolic blood pressure (
30224653
30578418
)
Interacting Genes
121 interacting genes:
ACTN1
ACTN2
AKT1
AR
ARHGDIA
ARNTL
ATF4
ATXN3
BRCA2
CCNA2
CCND1
CCNT1
CDC25B
CDCA4
CDK2
CDKN1B
CDT1
CEBPB
CEP250
CIITA
CLOCK
CREBBP
CTBP1
CTNNB1
CUX1
DACH2
DEK
EP300
ESRRA
ETV1
EZH2
GATAD2A
GATAD2B
H1-1
H1-5
H2AC20
H2AC4
H2BC21
H2BC3
H3-3A
H3-4
H3C1
H3C14
H4-16
H4C1
HIPK2
HMGA1
HMGN2
HNF1A
HNRNPU
HOXB9
HSD11B2
HTT
ING1
IRF1
IRF2
IRF7
JDP2
KLF10
KLF13
KLF2
LIN28B
MAPK14
MAPRE1
MDM2
MECOM
MYC
MYOD1
NCOA1
NCOA3
NCOA4
NFATC1
NFE2
NFE4
NOTCH1
NOTCH3
NPAS2
NR1H3
NR4A1
NRIP1
ONECUT1
PARP1
PDK1
PGR
PLAGL1
PNMA1
POLR2A
PTF1A
RAB11A
RARA
RB1
RBM8A
RBPJ
RELA
RPS6KB1
RPS6KB2
SAT2
SATB1
SERBP1
SERTAD1
SERTAD2
SIRT2
SMAD1
SMAD2
SMAD3
SRCAP
TACC2
TAL1
TCF3
TMF1
TP53
TP63
TP73
TRIM14
TTF1
TWIST1
UBE2D1
UBE2D2
UBE2D3
XRCC6
YY1
56 interacting genes:
ANP32A
ARID4A
ASF1A
ASF1B
BRD2
BRD4
BRD7
CBX5
CDY1
COPRS
CREBBP
DAXX
DNTTIP2
EP300
GADD45A
HAT1
HDAC6
HDAC8
HDAC9
ING2
KAT14
KAT2A
KAT2B
KAT5
KAT6A
KMT5A
L3MBTL1
LRWD1
MSL3
NCOA2
NCOA3
NOC2L
NSD1
ORC2
ORC3
ORC4
ORC5
PRMT1
PRMT5
PRMT6
RAG1
RBBP4
RPS6KA5
SAP30
SET
SETDB1
SIAH1
SMARCA5
TAF1A
TCF19
TP53BP1
UBE2I
UCHL5
USP16
VHL
WDR5
Entrez ID
8850
121504
HPRD ID
06780
13662
Ensembl ID
ENSG00000114166
ENSG00000197837
Uniprot IDs
Q92831
B2R4R0
P62805
PDB IDs
1CM0
1JM4
1N72
1WUG
1WUM
1ZS5
2RNW
2RNX
3GG3
4NSQ
5FDZ
5FE0
5FE1
5FE2
5FE3
5FE4
5FE5
5FE6
5FE7
5FE8
5FE9
5LVQ
5LVR
5MKX
6J3O
1ZKK
2BQZ
2CV5
2IG0
2KWN
2KWO
2LVM
2QQS
2RJE
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3IJ1
3JPX
3NQJ
3NQU
3O36
3QBY
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
3WA9
3WAA
3WKJ
3WTP
3X1S
3X1T
3X1U
3X1V
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
4M38
4N3W
4N4F
4QUT
4QUU
4QYD
4U9W
4YM5
4YM6
4YY6
4YYD
4YYG
4YYH
4YYI
4YYJ
4YYK
4YYM
4YYN
4Z2M
4Z5T
5AV5
5AV6
5AV8
5AV9
5AVB
5AVC
5AY8
5B0Y
5B0Z
5B24
5B2I
5B2J
5B31
5B32
5B33
5B40
5BNV
5BNX
5BO0
5C3I
5CPI
5CPJ
5CPK
5FA5
5FFW
5FWE
5GSE
5GSU
5GT0
5GT3
5GTC
5GXQ
5JA4
5JRG
5KDM
5TEG
5X7X
5XF3
5XF4
5XF5
5Y0C
5Y0D
5YE3
5YE4
5Z23
5Z30
5ZBX
5ZGC
6A5L
6A5O
6A5P
6A5R
6A5T
6A5U
6ACP
6BUZ
6C0W
6E0C
6E0P
6FML
6HKT
6HTS
6INQ
6IR9
6J4W
6J4X
6J4Y
6J4Z
6J50
6J51
6JOU
6JR0
6JR1
6K1I
6K1J
6K1K
6KE9
6KVD
6KXV
6L49
6L4A
6L9H
6LA8
6LA9
6LE9
6M3V
6M44
6M4D
6M4G
6M4H
6MLC
6MUO
6MUP
6O1D
6R0C
6R8Y
6R8Z
6R90
6R91
6R92
6R93
6R94
6RNY
6RXS
6SE0
6SE6
6SEE
6SEF
6SEG
6T79
6T7A
6T7B
6T7C
6T7D
6T90
6T93
6UPK
6UPL
6USJ
6V92
6VO5
6X59
6X5A
6XJD
6Y5D
6YOV
7A08
7C0M
7JO9
7JOA
Enriched GO Terms of Interacting Partners
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