POLR2A and UPF1

Data Source:
HPRD (in vitro)

		POLR2A	UPF1
Description		RNA polymerase II subunit A	UPF1 RNA helicase and ATPase
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GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Chromosome Nucleolus Cytoplasm	Chromosome, Telomeric Region Chromatin P-body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex
	Molecular Function	RNA Polymerase II Activity DNA Binding RNA Binding DNA-directed 5'-3' RNA Polymerase Activity RNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein C-terminus Binding Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Promoter-specific Chromatin Binding	Chromatin Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Telomeric DNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription, RNA-templated Transcription-coupled Nucleotide-excision Repair Transcription, DNA-templated DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Fibroblast Growth Factor Receptor Signaling Pathway Viral Process RNA Metabolic Process Positive Regulation Of RNA Splicing Somatic Stem Cell Population Maintenance SnRNA Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Regulation Of Gene Silencing By MiRNA	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Dosage Compensation By Inactivation Of X Chromosome Viral Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Telomere Maintenance Cell Cycle Phase Transition Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Histone MRNA Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 29760442) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Attention deficit hyperactivity disorder ( 32595297)
Interacting Genes		108 interacting genes: ABL1 ACTB ACTL6A ASB6 ATM BARD1 BRCA1 CALCOCO1 CALCOCO2 CASP10 CCNH CCNK CCNL2 CCNT1 CDC14A CDK12 CDK7 CDK8 CDK9 CPSF1 CPSF2 CPSF3 CREBBP CSH2 CSNK2A1 CSTF1 CSTF2 CTCF CTDP1 CTDSP1 CTDSP2 DHX9 ELL ELOA ERCC5 ERCC6 ERG ESR1 FUS GRB2 GTF2B GTF2E1 GTF2F1 GTF2H1 GTF2H4 H1-2 HNRNPF HNRNPU HTATSF1 IFTAP ITCH IWS1 KAT2B KLK2 KMT2D LEO1 MCM3 MED21 MNAT1 MYH6 NEDD4 NONO NR0B2 NSD1 OTUD5 PCIF1 PHF8 PIN1 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L PPIG PPP1CA PQBP1 PRMT5 PRPF19 PTEN SAFB SKP2 SMN1 SMN2 SMURF1 SNAR-B2 SND1 SUB1 SUMO2 SUPT5H TAF10 TBP TCEA1 TCERG1 TDRD3 TRAK1 TRAM2 TTK U2AF2 UBE2L3 UPF1 VDR WAC XAB2 XRCC5 ZNF74	103 interacting genes: ABHD16A ACSS2 ATR CSNK2B DCP1A DCP2 DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG HIRA LSM8 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NADSYN1 NDRG1 NDUFB10 PLEKHA5 PLEKHB2 POLR2A PTEN RHOXF2 RPRD2 SMG1 SMG5 STAU1 SUMO2 UPF2 UPF3A UPF3B XRN1
Entrez ID		5430	5976
HPRD ID		08916	03254
Ensembl ID		ENSG00000181222	ENSG00000005007
Uniprot IDs		P24928	A0A024R7L5 A0A024R7L8 B3KY55 Q92900
PDB IDs		2GHQ 2GHT 2LTO 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P 4JXT 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M3H 5M3J 6DRD 6F5P 6G0R 6IC8 6IC9 6O9L 6Q5Y	2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP 6EJ5 6Z3R
Enriched GO Terms of Interacting Partners?
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