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HDAC3 and PPP4C
Data Source:
HPRD
(in vivo)
HDAC3
PPP4C
Description
histone deacetylase 3
protein phosphatase 4 catalytic subunit
Image
No pdb structure
GO Annotations
Cellular Component
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Transcription Repressor Complex
Mitotic Spindle
Nucleoplasm
Microtubule Organizing Center
Cytosol
Plasma Membrane
Protein Phosphatase 4 Complex
Molecular Function
RNA Polymerase II Transcription Corepressor Binding
Chromatin Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Cyclin Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Histone Deacetylase Binding
NF-kappaB Binding
NF-kappaB-inducing Kinase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Metal Ion Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Protein Phosphorylation
Chromatin Organization
Protein Deacetylation
Circadian Rhythm
Negative Regulation Of Myotube Differentiation
Regulation Of Lipid Metabolic Process
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Positive Regulation Of TOR Signaling
Circadian Regulation Of Gene Expression
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Spindle Assembly
Histone H3 Deacetylation
Histone H4 Deacetylation
Cellular Response To Fluid Shear Stress
Positive Regulation Of Cold-induced Thermogenesis
Protein Dephosphorylation
Regulation Of Double-strand Break Repair Via Homologous Recombination
NIK/NF-kappaB Signaling
Pathways
NR1D1 (REV-ERBA) represses gene expression
p75NTR negatively regulates cell cycle via SC1
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Association of TriC/CCT with target proteins during biosynthesis
Regulation of lipid metabolism by PPARalpha
Circadian Clock
Circadian Clock
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
Processing of DNA double-strand break ends
Drugs
Vorinostat
Belinostat
Pracinostat
Panobinostat
Mocetinostat
Diseases
GWAS
Refractive error (
32231278
)
Adventurousness (
30643258
)
Autism spectrum disorder or schizophrenia (
28540026
)
Body fat distribution (arm fat ratio) (
30664634
)
Brain morphology (MOSTest) (
32665545
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Eosinophil percentage of white cells (
32888494
)
Mean corpuscular volume (
29403010
)
Medication use (diuretics) (
31015401
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
102 interacting genes:
ANKRD11
ANKRD12
AR
ARID4A
ATF3
BCL3
BCOR
BRINP1
BRIP1
BRMS1
CBFA2T3
CCN5
CCND1
CCT5
CEBPD
CORO2A
CREB3
CREBBP
CSNK2A1
CTBP1
DAXX
DHX30
EED
ELL
EP300
ESR1
EWSR1
GATA1
GATA2
GATA3
GCM1
GPS2
GTF2I
GTF2IRD1
H2AC1
H2BC1
H3C1
H4C1
HDAC1
HDAC10
HDAC4
HDAC5
HDAC7
HDAC9
HIF1A
HIF1AN
HNF4A
HR
HSPA4
HSPA8
IL16
JUN
KLF6
LCOR
MAPK11
MAPK14
MBD1
NACC1
NCOR1
NCOR2
NFKBIA
NR0B2
NR2C1
NR2E3
NRIP1
PARP1
PHB2
PIAS2
PML
PPARD
PPARG
PPP4C
PPP4R1
PRKDC
RARA
RB1
RBBP4
RELA
RUNX1T1
RUNX2
RXRA
SMYD1
SRC
SRY
STAT3
SUV39H1
SYK
TAB2
TBL1X
TBL1XR1
THAP11
THAP7
THRA
THRB
TMPO
TNFRSF14
TP53
TXNIP
VHL
XPO1
YY1
ZBTB16
21 interacting genes:
CCDC6
DHX38
GPANK1
HDAC3
IGBP1
JUN
NFKB1
PPP2R1A
PPP2R5D
PPP4R1
PPP4R2
PPP4R3B
PPP4R4
REL
RELA
RPA2
TIPRL
TK1
TMSB4X
TP53
TRAF6
Entrez ID
8841
5531
HPRD ID
08950
03615
Ensembl ID
ENSG00000171720
ENSG00000149923
Uniprot IDs
O15379
A0A024R625
P60510
PDB IDs
4A69
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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