HDAC3 and THAP7

Data Source:
BioGRID (pull down)

		HDAC3	THAP7
Description		histone deacetylase 3	THAP domain containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Transcription Repressor Complex Mitotic Spindle	Nucleus Nucleoplasm Chromosome Nuclear Speck Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Enzyme Binding Cyclin Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding NF-kappaB Binding	RNA Polymerase II Transcription Corepressor Binding DNA Binding Protein Binding Nucleosomal Histone Binding Methylated Histone Binding Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding Protein N-terminus Binding Lysine-acetylated Histone Binding C2H2 Zinc Finger Domain Binding Phosphorylated Histone Binding General Transcription Initiation Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Chromatin Organization Protein Deacetylation Circadian Rhythm Negative Regulation Of Myotube Differentiation Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Spindle Assembly Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Fluid Shear Stress Positive Regulation Of Cold-induced Thermogenesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated
Pathways		NR1D1 (REV-ERBA) represses gene expression p75NTR negatively regulates cell cycle via SC1 PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Association of TriC/CCT with target proteins during biosynthesis Regulation of lipid metabolism by PPARalpha Circadian Clock Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs		Vorinostat Belinostat Pracinostat Panobinostat Mocetinostat
Diseases
GWAS		Refractive error ( 32231278)
Interacting Genes		102 interacting genes: ANKRD11 ANKRD12 AR ARID4A ATF3 BCL3 BCOR BRINP1 BRIP1 BRMS1 CBFA2T3 CCN5 CCND1 CCT5 CEBPD CORO2A CREB3 CREBBP CSNK2A1 CTBP1 DAXX DHX30 EED ELL EP300 ESR1 EWSR1 GATA1 GATA2 GATA3 GCM1 GPS2 GTF2I GTF2IRD1 H2AC1 H2BC1 H3C1 H4C1 HDAC1 HDAC10 HDAC4 HDAC5 HDAC7 HDAC9 HIF1A HIF1AN HNF4A HR HSPA4 HSPA8 IL16 JUN KLF6 LCOR MAPK11 MAPK14 MBD1 NACC1 NCOR1 NCOR2 NFKBIA NR0B2 NR2C1 NR2E3 NRIP1 PARP1 PHB2 PIAS2 PML PPARD PPARG PPP4C PPP4R1 PRKDC RARA RB1 RBBP4 RELA RUNX1T1 RUNX2 RXRA SMYD1 SRC SRY STAT3 SUV39H1 SYK TAB2 TBL1X TBL1XR1 THAP11 THAP7 THRA THRB TMPO TNFRSF14 TP53 TXNIP VHL XPO1 YY1 ZBTB16	63 interacting genes: ANKRD28 APP CCDC136 CCDC85B CCNDBP1 CDC37 CYSRT1 DESI2 DVL3 EFEMP2 EHMT2 FBXO7 FHL3 FSD2 GABARAPL1 GNAI1 GOLGA2 GOLGA6L9 H3C1 H4C1 HCFC1 HDAC3 HOXA1 KRT27 KRT31 KRT34 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP17-1 KRTAP4-12 LDOC1 LNX1 LURAP1 LZTS2 MAGOHB MAP1LC3B MCC MDFI MID2 MTUS2 NBPF19 NOTCH2NLA NTAQ1 PELI2 PHC2 PHF19 PICK1 PIN1 PNMA2 PPP3CC SET TAF1B TFIP11 THAP11 TLE5 TPM3 TRAF1 TRAF2 TRAF5 ZDHHC17 ZRANB1
Entrez ID		8841	80764
HPRD ID		08950	15500
Ensembl ID		ENSG00000171720	ENSG00000184436
Uniprot IDs		O15379	Q9BT49
PDB IDs		4A69
Enriched GO Terms of Interacting Partners?
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