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HDAC3 and NCOR2
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD
(in vitro)
HDAC3
NCOR2
Description
histone deacetylase 3
nuclear receptor corepressor 2
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Transcription Repressor Complex
Mitotic Spindle
Histone Deacetylase Complex
Chromatin
Nucleus
Nucleoplasm
Membrane
Nuclear Matrix
Nuclear Body
Transcription Repressor Complex
Molecular Function
RNA Polymerase II Transcription Corepressor Binding
Chromatin Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Cyclin Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Histone Deacetylase Binding
NF-kappaB Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Transcription Corepressor Activity
Notch Binding
Protein Binding
Nuclear Hormone Receptor Binding
Glucocorticoid Receptor Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Retinoid X Receptor Binding
Protein N-terminus Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Protein Phosphorylation
Chromatin Organization
Protein Deacetylation
Circadian Rhythm
Negative Regulation Of Myotube Differentiation
Regulation Of Lipid Metabolic Process
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Positive Regulation Of TOR Signaling
Circadian Regulation Of Gene Expression
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Spindle Assembly
Histone H3 Deacetylation
Histone H4 Deacetylation
Cellular Response To Fluid Shear Stress
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Transcription By RNA Polymerase II
Lactation
Response To Organonitrogen Compound
Regulation Of Cellular Ketone Metabolic Process
Regulation Of Lipid Metabolic Process
Response To Estradiol
Estrous Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Pathways
NR1D1 (REV-ERBA) represses gene expression
p75NTR negatively regulates cell cycle via SC1
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Association of TriC/CCT with target proteins during biosynthesis
Regulation of lipid metabolism by PPARalpha
Circadian Clock
Circadian Clock
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs
Vorinostat
Belinostat
Pracinostat
Panobinostat
Mocetinostat
Diseases
GWAS
Refractive error (
32231278
)
Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) (
23648065
)
Appendicular lean mass (
33097823
)
Clubfoot (
24667120
)
Cocaine dependence (
23958962
)
Cognitive performance (
19734545
)
Diastolic blood pressure (
30224653
)
HDL cholesterol levels (
32203549
)
Height (
31562340
)
Lung function (FEV1) (
30061609
)
Mean spheric corpuscular volume (
32888494
)
Mosquito bite size (
28199695
)
Multiple sclerosis (
31604244
)
Platelet distribution width (
32888494
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
102 interacting genes:
ANKRD11
ANKRD12
AR
ARID4A
ATF3
BCL3
BCOR
BRINP1
BRIP1
BRMS1
CBFA2T3
CCN5
CCND1
CCT5
CEBPD
CORO2A
CREB3
CREBBP
CSNK2A1
CTBP1
DAXX
DHX30
EED
ELL
EP300
ESR1
EWSR1
GATA1
GATA2
GATA3
GCM1
GPS2
GTF2I
GTF2IRD1
H2AC1
H2BC1
H3C1
H4C1
HDAC1
HDAC10
HDAC4
HDAC5
HDAC7
HDAC9
HIF1A
HIF1AN
HNF4A
HR
HSPA4
HSPA8
IL16
JUN
KLF6
LCOR
MAPK11
MAPK14
MBD1
NACC1
NCOR1
NCOR2
NFKBIA
NR0B2
NR2C1
NR2E3
NRIP1
PARP1
PHB2
PIAS2
PML
PPARD
PPARG
PPP4C
PPP4R1
PRKDC
RARA
RB1
RBBP4
RELA
RUNX1T1
RUNX2
RXRA
SMYD1
SRC
SRY
STAT3
SUV39H1
SYK
TAB2
TBL1X
TBL1XR1
THAP11
THAP7
THRA
THRB
TMPO
TNFRSF14
TP53
TXNIP
VHL
XPO1
YY1
ZBTB16
89 interacting genes:
ADRB2
AHR
AKT1
AP2M1
AR
ARNT
ATXN1
ATXN1L
BCL6
C1D
CBFA2T2
CDK2
CEBPB
CEP63
CHUK
CIR1
CNOT2
DDX20
E2F1
ESR1
ESR2
FOS
FOXP1
H4C1
HDAC1
HDAC10
HDAC3
HDAC4
HDAC5
HDAC7
HNF4A
INPP5K
IRF5
JUN
KLF5
MYBL2
MYOD1
NCOA3
NCOA6
NCOR1
NFE2L2
NFKB1
NFKBIA
NFKBIB
NFKBIE
NR1D1
NR1H2
NR1H4
NR1I2
NR2F1
NR2F2
NR3C1
NR4A1
PIN1
PML
POU2F1
PPARA
PPARD
PPARG
RANBP9
RARA
RARB
RARG
RBPJ
RELA
RUNX1
RUNX1T1
RXRA
RXRG
SAP30
SIN3A
SKIL
SNW1
SP1
SPEN
SRF
STAT5A
STAT5B
SUMO1
TBL1X
THRA
THRB
TNIK
TNIP2
UBE2I
VDR
YWHAE
ZBTB16
ZBTB7A
Entrez ID
8841
9612
HPRD ID
08950
02910
Ensembl ID
ENSG00000171720
ENSG00000196498
Uniprot IDs
O15379
C9J0Q5
C9JE98
Q9Y618
PDB IDs
4A69
1KKQ
1R2B
1XC5
2GPV
2L5G
2LTP
2ODD
2RT5
3R29
3R2A
4A69
4OAR
5X8Q
5X8X
5ZOO
5ZOP
6A22
6IVX
6PDZ
Enriched GO Terms of Interacting Partners
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