PPP4C and IGBP1

Data Source:
HPRD (two hybrid)

		PPP4C	IGBP1
Description		protein phosphatase 4 catalytic subunit	immunoglobulin binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Microtubule Organizing Center Cytosol Plasma Membrane Protein Phosphatase 4 Complex	Cytoplasm Cytosol
	Molecular Function	NF-kappaB-inducing Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding
	Biological Process	Protein Dephosphorylation Regulation Of Double-strand Break Repair Via Homologous Recombination NIK/NF-kappaB Signaling	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Negative Regulation Of Stress-activated MAPK Cascade Response To Tumor Necrosis Factor Regulation Of Dephosphorylation B Cell Activation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Microtubule-based Movement Response To Interleukin-1
Pathways		Processing of DNA double-strand break ends
Drugs
Diseases			Corpus callosum, agenesis of, with mental retardation, ocular coloboma and micrognathia
GWAS		Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 29403010) Medication use (diuretics) ( 31015401) Schizophrenia ( 25056061 29483656)
Interacting Genes		21 interacting genes: CCDC6 DHX38 GPANK1 HDAC3 IGBP1 JUN NFKB1 PPP2R1A PPP2R5D PPP4R1 PPP4R2 PPP4R3B PPP4R4 REL RELA RPA2 TIPRL TK1 TMSB4X TP53 TRAF6	12 interacting genes: APP HSPB1 LINC01257 MID1 MID2 PPP2CA PPP4C PPP6C PYGM REXO5 S100A13 SHOX
Entrez ID		5531	3476
HPRD ID		03615	02140
Ensembl ID		ENSG00000149923	ENSG00000089289
Uniprot IDs		A0A024R625 P60510	P78318
PDB IDs			4IYP
Enriched GO Terms of Interacting Partners?
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