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EIF3I and EXOSC6
Data Source:
HPRD
(two hybrid)
EIF3I
EXOSC6
Description
eukaryotic translation initiation factor 3 subunit I
exosome component 6
Image
GO Annotations
Cellular Component
Cytosol
Eukaryotic Translation Initiation Factor 3 Complex
Eukaryotic 43S Preinitiation Complex
Eukaryotic 48S Preinitiation Complex
Extracellular Exosome
Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleoplasm
Nucleolus
Cytosol
Molecular Function
RNA Binding
Translation Initiation Factor Activity
Protein Binding
RNA Binding
Exoribonuclease Activity
Biological Process
Formation Of Cytoplasmic Translation Initiation Complex
Cytoplasmic Translational Initiation
Translational Initiation
RRNA Processing
RRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
DNA Deamination
Isotype Switching
Positive Regulation Of Isotype Switching
Nuclear MRNA Surveillance
Polyadenylation-dependent SnoRNA 3'-end Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways
L13a-mediated translational silencing of Ceruloplasmin expression
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Malaria (
31844061
)
Interacting Genes
12 interacting genes:
EIF3A
EIF3B
EIF4G1
ERCC6
ESR1
EXOSC6
LIG4
METTL3
PAXIP1
SUMO4
TGFB1
TGFBR2
37 interacting genes:
C1QBP
CHPF
DCP1B
DIS3
DNAJC30
EIF3I
ESRRA
EXOSC1
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC7
EXOSC8
EXOSC9
GSE1
HBS1L
LSM1
LSM7
LSM8
MAN2C1
MIF4GD
MOCS3
MPHOSPH6
MRPL4
MRPS18B
MTREX
NDUFA13
NUDT21
PALS2
PSMB1
RAB3GAP2
SRSF3
TUFM
UPF2
XRN1
ZFP36
Entrez ID
8668
118460
HPRD ID
04884
12107
Ensembl ID
ENSG00000084623
ENSG00000223496
Uniprot IDs
Q13347
Q5U0F4
Q5RKV6
PDB IDs
6YBT
6ZMW
6ZON
6ZP4
6ZVJ
7A09
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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